The Lysophosphatidic Acid Type 2 Receptor Is Required for Protection Against Radiation-Induced Intestinal Injury

Background & Aims: We recently identified lysophosphatidic acid (LPA) as a potent antiapoptotic agent for the intestinal epithelium. The objective of the present study was to evaluate the effect of octadecenyl thiophosphate (OTP), a novel rationally designed, metabolically stabilized LPA mimic,...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2007-05, Vol.132 (5), p.1834-1851
Hauptverfasser:	Deng, Wenlin, E, Shuyu, Tsukahara, Ryoko, Valentine, William J, Durgam, Gangadhar, Gududuru, Veeresa, Balazs, Louisa, Manickam, Venkatraman, Arsura, Marcello, Vanmiddlesworth, Lester, Johnson, Leonard R, Parrill, Abby L, Miller, Duane D, Tigyi, Gabor
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Apoptosis - drug effects Apoptosis - physiology Apoptosis - radiation effects Cell Line Cells, Cultured Dose-Response Relationship, Drug Female Gamma Rays - adverse effects Gastroenterology and Hepatology Gene Expression Regulation GTP-Binding Proteins - physiology Injections, Intraperitoneal Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinases - physiology Nerve Tissue Proteins - pharmacology Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - pharmacology Phosphatidylinositol 3-Kinases - physiology Radiation Injuries, Experimental - metabolism Radiation Injuries, Experimental - pathology Radiation Injuries, Experimental - prevention & control Receptors, Lysophosphatidic Acid - genetics Receptors, Lysophosphatidic Acid - physiology Signal Transduction - physiology Tumor Necrosis Factor-alpha - pharmacology
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