K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance

Potassium channels exhibit a large diversity of single-channel conductances. Shaker is a low-conductance K-channel in which Pro475→Asp, a single-point mutation near the internal pore entrance, promotes 6- to 8-fold higher unitary current. To assess the mechanism for this higher conductance, we measu...

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Veröffentlicht in:	Biophysical journal 2012-09, Vol.103 (6), p.1198-1207
Hauptverfasser:	Moscoso, Cristian, Vergara-Jaque, Ariela, Márquez-Miranda, Valeria, Sepúlveda, Romina V., Valencia, Ignacio, Díaz-Franulic, Ignacio, González-Nilo, Fernando, Naranjo, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological Transport - drug effects Channels and Transporters Electric Conductivity electric power energy Intracellular Space - drug effects Intracellular Space - metabolism ions magnesium Magnesium - pharmacology molecular dynamics Molecular Dynamics Simulation mutants mutation Point Mutation Porosity potassium Potassium - metabolism Potassium Channel Blockers - pharmacology potassium channels Protein Conformation Shaker Superfamily of Potassium Channels - antagonists & inhibitors Shaker Superfamily of Potassium Channels - chemistry Shaker Superfamily of Potassium Channels - genetics Shaker Superfamily of Potassium Channels - metabolism Static Electricity Xenopus laevis
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