Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration

Acquired tamoxifen resistance involves complex signaling events that are not yet fully understood. Successful therapeutic intervention to delay the onset of hormone resistance depends critically on mechanistic elucidation of viable molecular targets associated with hormone resistance. This study was...

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Veröffentlicht in:	Breast cancer research : BCR 2012-03, Vol.14 (2), p.R45-R45, Article R45
Hauptverfasser:	Zhou, Changhua, Zhong, Qiu, Rhodes, Lyndsay V, Townley, Ian, Bratton, Melyssa R, Zhang, Qiang, Martin, Elizabeth C, Elliott, Steven, Collins-Burow, Bridgette M, Burow, Matthew E, Wang, Guangdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Antineoplastic Agents, Hormonal - pharmacology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cancer cells Cell Line, Tumor Cell Movement Development and progression Down-Regulation - drug effects Drug Resistance, Neoplasm Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Humans Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Physiological aspects Proteomics - methods Receptors, Estrogen - metabolism Signal Transduction - drug effects Tamoxifen Tamoxifen - pharmacology Tandem Mass Spectrometry
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