Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcome

Polo-like kinase-1 (PLK1) is a crucial driver of cell cycle progression and its down-regulation plays an important checkpoint role in response to DNA damage. Mechanistically, this is mediated by p53 which represses PLK1 expression through chromatin remodelling. Consistent with this model, cultured c...

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Veröffentlicht in:	Breast cancer research : BCR 2012-01, Vol.14 (2), p.R40-R40
Hauptverfasser:	King, Sharon I, Purdie, Colin A, Bray, Susan E, Quinlan, Philip R, Jordan, Lee B, Thompson, Alastair M, Meek, David W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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