A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this toxicity. A prospective pharmacogenetic analysis of patients with primary breast cancer, randomized to the pa...

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Veröffentlicht in:	Clinical cancer research 2012-09, Vol.18 (18), p.5099-5109
Hauptverfasser:	MICHAEL BALDWIN, R, OWZAR, Kouros, FRIEDMAN, Paula N, HUDIS, Clifford A, WINER, Eric P, JORGENSON, Eric M, WITTE, John S, SHULMAN, Lawrence N, NAKAMURA, Yusuke, RATAIN, Mark J, KROETZ, Deanna L, ZEMBUTSU, Hitoshi, CHHIBBER, Aparna, KUBO, Michiaki, JIANG, Chen, WATSON, Dorothy, ECLOV, Rachel J, MEFFORD, Joel, MCLEOD, Howard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Breast Neoplasms - complications Breast Neoplasms - drug therapy Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Incidence Medical sciences Microfilament Proteins - genetics Middle Aged Paclitaxel - adverse effects Paclitaxel - therapeutic use Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - genetics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Receptor, EphA5 - genetics Sensory Receptor Cells - drug effects
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