In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix
► Aqueous cinnamon extract lowered fasting blood glucose in diet induced obese mice. ► Cinnamon polyphenol-enriched flour lowered blood glucose in diet induced obese mice. ► Cinnamon polyphenols inhibited hepatic glucose production. ► Cinnamon extract decreased gene expression of glucose-6-phosphata...
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| creator | Cheng, Diana M. Kuhn, Peter Poulev, Alexander Rojo, Leonel E. Lila, Mary Ann Raskin, Ilya |
| description | ► Aqueous cinnamon extract lowered fasting blood glucose in diet induced obese mice. ► Cinnamon polyphenol-enriched flour lowered blood glucose in diet induced obese mice. ► Cinnamon polyphenols inhibited hepatic glucose production. ► Cinnamon extract decreased gene expression of glucose-6-phosphatase. ► Cinnamon extract decreased gene expression of phosphoenolpyruvate carboxykinase.
Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1–25μg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25μg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions. |
| doi_str_mv | 10.1016/j.foodchem.2012.06.117 |
| format | Article |
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Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1–25μg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25μg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2012.06.117</identifier><identifier>PMID: 22980902</identifier><identifier>CODEN: FOCHDJ</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Aroma and flavouring agent industries ; Biological and medical sciences ; blood glucose ; Cell Line ; Cinnamomum burmannii ; Cinnamomum zeylanicum - chemistry ; Cinnamon ; Diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - enzymology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; diet ; Fasting blood glucose ; Food industries ; food matrix ; functional foods ; Fundamental and applied biological sciences. Psychology ; gene expression ; gluconeogenesis ; glucose ; Glucose - metabolism ; Glucose production ; Glucose-6-Phosphatase - genetics ; Glucose-6-Phosphatase - metabolism ; glycemic effect ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; ingredients ; Male ; mechanism of action ; Mice ; Mice, Inbred C57BL ; noninsulin-dependent diabetes mellitus ; Phosphoenolpyruvate Carboxykinase (ATP) - genetics ; Phosphoenolpyruvate Carboxykinase (ATP) - metabolism ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; polyphenols ; Polyphenols - administration & dosage ; Polyphenols - pharmacology ; proteins ; Rats ; soy flour ; Soy Foods - analysis</subject><ispartof>Food chemistry, 2012-12, Vol.135 (4), p.2994-3002</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>2012 Elsevier Ltd. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-98366d1cb0bb7e3bd610092041bdc790adf4307b636a5a446ba9d970945e91bd3</citedby><cites>FETCH-LOGICAL-c525t-98366d1cb0bb7e3bd610092041bdc790adf4307b636a5a446ba9d970945e91bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2012.06.117$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26385192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22980902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Diana M.</creatorcontrib><creatorcontrib>Kuhn, Peter</creatorcontrib><creatorcontrib>Poulev, Alexander</creatorcontrib><creatorcontrib>Rojo, Leonel E.</creatorcontrib><creatorcontrib>Lila, Mary Ann</creatorcontrib><creatorcontrib>Raskin, Ilya</creatorcontrib><title>In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>► Aqueous cinnamon extract lowered fasting blood glucose in diet induced obese mice. ► Cinnamon polyphenol-enriched flour lowered blood glucose in diet induced obese mice. ► Cinnamon polyphenols inhibited hepatic glucose production. ► Cinnamon extract decreased gene expression of glucose-6-phosphatase. ► Cinnamon extract decreased gene expression of phosphoenolpyruvate carboxykinase.
Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1–25μg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25μg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions.</description><subject>Animals</subject><subject>Aroma and flavouring agent industries</subject><subject>Biological and medical sciences</subject><subject>blood glucose</subject><subject>Cell Line</subject><subject>Cinnamomum burmannii</subject><subject>Cinnamomum zeylanicum - chemistry</subject><subject>Cinnamon</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - enzymology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>diet</subject><subject>Fasting blood glucose</subject><subject>Food industries</subject><subject>food matrix</subject><subject>functional foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene expression</subject><subject>gluconeogenesis</subject><subject>glucose</subject><subject>Glucose - metabolism</subject><subject>Glucose production</subject><subject>Glucose-6-Phosphatase - genetics</subject><subject>Glucose-6-Phosphatase - metabolism</subject><subject>glycemic effect</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>ingredients</subject><subject>Male</subject><subject>mechanism of action</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Phosphoenolpyruvate Carboxykinase (ATP) - genetics</subject><subject>Phosphoenolpyruvate Carboxykinase (ATP) - metabolism</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>polyphenols</subject><subject>Polyphenols - administration & dosage</subject><subject>Polyphenols - pharmacology</subject><subject>proteins</subject><subject>Rats</subject><subject>soy flour</subject><subject>Soy Foods - analysis</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFCEYgInR2LX6FyoXEy8zvgwMDBejadQ2aeJBeyYMMF02M7DC7Kb99zLudq0nT3w97wfvg9AFgZoA4R829RCjNWs31Q2QpgZeEyKeoRXpBK0EiOY5WgGFruoI42foVc4bAChs9xKdNY3sQEKzQuk64L3fR6yDxX7Zz2k5zN563bvZG-yGwZk54zhg_Wvn4i5j40PQUwzY3c9Jm_lP9OlyG8eH7dqFOFYurHUwzuKlWzzpOfn71-jFoMfs3hzXc3T79cvPy6vq5vu368vPN5Vpm3auZEc5t8T00PfC0d5yAiAbYKS3RkjQdmAURM8p161mjPdaWilAstbJwtBz9PGQd7vrJ2eNC6XXUW2Tn3R6UFF79e9L8Gt1F_eKMsYEkyXB-2OCFMvH86wmn40bRx2WKSgCDKSUDRUF5QfUpJhzcsOpDAG1CFMb9ShMLcIUcFWElcCLp02ewh4NFeDdEdDZ6HFIZZ4-_-U47VoiF-7tgRt0VPouFeb2R6nEoCjnRNJCfDoQrgx9711S2Xi32PGpCFY2-v91-xtL5cN3</recordid><startdate>20121215</startdate><enddate>20121215</enddate><creator>Cheng, Diana M.</creator><creator>Kuhn, Peter</creator><creator>Poulev, Alexander</creator><creator>Rojo, Leonel E.</creator><creator>Lila, Mary Ann</creator><creator>Raskin, Ilya</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121215</creationdate><title>In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix</title><author>Cheng, Diana M. ; Kuhn, Peter ; Poulev, Alexander ; Rojo, Leonel E. ; Lila, Mary Ann ; Raskin, Ilya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-98366d1cb0bb7e3bd610092041bdc790adf4307b636a5a446ba9d970945e91bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Aroma and flavouring agent industries</topic><topic>Biological and medical sciences</topic><topic>blood glucose</topic><topic>Cell Line</topic><topic>Cinnamomum burmannii</topic><topic>Cinnamomum zeylanicum - chemistry</topic><topic>Cinnamon</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - enzymology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>diet</topic><topic>Fasting blood glucose</topic><topic>Food industries</topic><topic>food matrix</topic><topic>functional foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene expression</topic><topic>gluconeogenesis</topic><topic>glucose</topic><topic>Glucose - metabolism</topic><topic>Glucose production</topic><topic>Glucose-6-Phosphatase - genetics</topic><topic>Glucose-6-Phosphatase - metabolism</topic><topic>glycemic effect</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>ingredients</topic><topic>Male</topic><topic>mechanism of action</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Phosphoenolpyruvate Carboxykinase (ATP) - genetics</topic><topic>Phosphoenolpyruvate Carboxykinase (ATP) - metabolism</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>polyphenols</topic><topic>Polyphenols - administration & dosage</topic><topic>Polyphenols - pharmacology</topic><topic>proteins</topic><topic>Rats</topic><topic>soy flour</topic><topic>Soy Foods - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Diana M.</creatorcontrib><creatorcontrib>Kuhn, Peter</creatorcontrib><creatorcontrib>Poulev, Alexander</creatorcontrib><creatorcontrib>Rojo, Leonel E.</creatorcontrib><creatorcontrib>Lila, Mary Ann</creatorcontrib><creatorcontrib>Raskin, Ilya</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Diana M.</au><au>Kuhn, Peter</au><au>Poulev, Alexander</au><au>Rojo, Leonel E.</au><au>Lila, Mary Ann</au><au>Raskin, Ilya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2012-12-15</date><risdate>2012</risdate><volume>135</volume><issue>4</issue><spage>2994</spage><epage>3002</epage><pages>2994-3002</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><coden>FOCHDJ</coden><abstract>► Aqueous cinnamon extract lowered fasting blood glucose in diet induced obese mice. ► Cinnamon polyphenol-enriched flour lowered blood glucose in diet induced obese mice. ► Cinnamon polyphenols inhibited hepatic glucose production. ► Cinnamon extract decreased gene expression of glucose-6-phosphatase. ► Cinnamon extract decreased gene expression of phosphoenolpyruvate carboxykinase.
Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1–25μg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25μg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22980902</pmid><doi>10.1016/j.foodchem.2012.06.117</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Aroma and flavouring agent industries Biological and medical sciences blood glucose Cell Line Cinnamomum burmannii Cinnamomum zeylanicum - chemistry Cinnamon Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism diet Fasting blood glucose Food industries food matrix functional foods Fundamental and applied biological sciences. Psychology gene expression gluconeogenesis glucose Glucose - metabolism Glucose production Glucose-6-Phosphatase - genetics Glucose-6-Phosphatase - metabolism glycemic effect Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology ingredients Male mechanism of action Mice Mice, Inbred C57BL noninsulin-dependent diabetes mellitus Phosphoenolpyruvate Carboxykinase (ATP) - genetics Phosphoenolpyruvate Carboxykinase (ATP) - metabolism Plant Extracts - administration & dosage Plant Extracts - pharmacology polyphenols Polyphenols - administration & dosage Polyphenols - pharmacology proteins Rats soy flour Soy Foods - analysis |
| title | In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix |
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