SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

SIRT1 is a NAD +-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms. Behavioral responses to food abundance are important for the survival of higher animals. Here we used mice with increased or decreased brain SIRT1 t...

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Veröffentlicht in:	Cell 2011-12, Vol.147 (7), p.1459-1472
Hauptverfasser:	Libert, Sergiy, Pointer, Kelli, Bell, Eric L., Das, Abhirup, Cohen, Dena E., Asara, John M., Kapur, Karen, Bergmann, Sven, Preisig, Martin, Otowa, Takeshi, Kendler, Kenneth S., Chen, Xiangning, Hettema, John M., van den Oord, Edwin J., Rubio, Justin P., Guarente, Leonard
Format:	Artikel
Sprache:	eng
Schlagworte:	amine oxidase (flavin-containing) Amino Acid Sequence Animals Anxiety Anxiety - genetics Behavior, Animal Brain Brain - metabolism Data processing Drive Exploratory Behavior Food availability Gene Expression Regulation genes Helix Helix-loop-helix proteins human population Humans Lysine Mice Molecular Sequence Data Monoamine Oxidase - chemistry Monoamine Oxidase - genetics mutants Nutritional status Polymorphism, Single Nucleotide Promoter Regions, Genetic Promoters risk serotonin Serotonin uptake inhibitors SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Sirtuins transcription (genetics) Transcription factors Transcription Factors - genetics
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