A Systematic Family-wide Investigation Reveals that ∼30% of Mammalian PDZ Domains Engage in PDZ-PDZ Interactions

PDZ domains are independently folded modules that typically mediate protein-protein interactions by binding to the C termini of their target proteins. However, in a few instances, PDZ domains have been reported to dimerize with other PDZ domains. To investigate this noncanonical-binding mode further...

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Veröffentlicht in:	Chemistry & biology 2011-09, Vol.18 (9), p.1143-1152
Hauptverfasser:	Chang, Bryan H., Gujral, Taranjit S., Karp, Ethan S., BuKhalid, Raghida, Grantcharova, Viara P., MacBeath, Gavin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Dimerization Fluorescence Polarization Humans Mice PDZ Domains Protein Array Analysis Protein Binding Protein Interaction Maps Proteins - chemistry Proteins - metabolism Proteome - chemistry Proteome - metabolism
Online-Zugang:	Volltext
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