GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation

GATA-6 is a zinc-finger transcription factor essential for early embryogenesis. Ablation of GATA-6 in mice impairs endoderm differentiation and causes apoptosis of epiblast cells. The endoderm defects have been attributed to the loss of HNF4, disabled-2, and GATA-4. However, the mechanisms underlyin...

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Veröffentlicht in:	Molecular biology of the cell 2012-09, Vol.23 (18), p.3754-3763
Hauptverfasser:	Rong, Li, Liu, Jie, Qi, Yanmei, Graham, Alan M, Parmacek, Michael S, Li, Shaohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - genetics Bone Morphogenetic Protein 2 - genetics Bone Morphogenetic Protein 2 - metabolism Bone Morphogenetic Protein 2 - pharmacology Cell Differentiation Cell Line Cell Survival Embryoid Bodies - cytology Embryoid Bodies - metabolism Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Endoderm - metabolism Endoderm - ultrastructure GATA6 Transcription Factor - genetics GATA6 Transcription Factor - metabolism Gene Expression Profiling Germ Layers - metabolism Immunoblotting Mice Microscopy, Electron Microscopy, Fluorescence Mutation Phosphorylation Promoter Regions, Genetic - genetics Protein Binding Reverse Transcriptase Polymerase Chain Reaction Smad Proteins - genetics Smad Proteins - metabolism Time Factors Up-Regulation
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