Expression profiles of human interferon‐alpha and interferon‐lambda subtypes are ligand‐ and cell‐dependent

Recent genome‐wide association studies suggest distinct roles for 12 human interferon‐alpha (IFN‐α) and 3 IFN‐λ subtypes that may be elucidated by defining the expression patterns of these sets of genes. To overcome the impediment of high homology among each of the sets, we designed a quantitative r...

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Veröffentlicht in:	Immunology and cell biology 2012-09, Vol.90 (8), p.774-783
Hauptverfasser:	Hillyer, Philippa, Mane, Viraj P, Schramm, Lynnsie M, Puig, Montserrat, Verthelyi, Daniela, Chen, Aaron, Zhao, Zeng, Navarro, Maria B, Kirschman, Kevin D, Bykadi, Srikant, Jubin, Ronald G, Rabin, Ronald L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals dendritic cell Dendritic Cells - drug effects Dendritic Cells - metabolism DNA Probes - metabolism Gene Expression Profiling Gene Expression Regulation - drug effects Humans Interferon-alpha - genetics Interferon-alpha - metabolism Interferons interferon‐α interferon‐λ Interleukins - genetics Interleukins - metabolism Ligands Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Myeloid Cells - drug effects Myeloid Cells - metabolism Oligodeoxyribonucleotides - pharmacology Organ Specificity - drug effects Organ Specificity - genetics Original Poly I-C - pharmacology qRT‐PCR Reproducibility of Results RNA, Messenger - genetics RNA, Messenger - metabolism Toll-Like Receptors - metabolism Toll‐like receptor
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