Activation of the stress proteome as a mechanism for small molecule therapeutics

Various small molecule pharmacologic agents with different known functions produce similar outcomes in diverse Mendelian and complex disorders, suggesting that they may induce common cellular effects. These molecules include histone deacetylase inhibitors, 4-phenylbutyrate (4PBA) and trichostatin A,...

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Veröffentlicht in:	Human molecular genetics 2012-10, Vol.21 (19), p.4237-4252
Hauptverfasser:	DEERING BROSE, Rebecca, SHIN, Gloria, MCGUINNESS, Martina C, SCHNEIDEREITH, Tonya, PURVIS, Shirley, DONG, Gao X, KEEFER, Jeffrey, SPENCER, Forrest, SMITH, Kirby D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenoleukodystrophy - drug therapy Adrenoleukodystrophy - genetics Adrenoleukodystrophy - metabolism Adrenoleukodystrophy - physiopathology Biological and medical sciences Cell Line Diverse techniques Drug Therapy Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humans Hydroxamic Acids - therapeutic use Hydroxyurea - therapeutic use Isothiocyanates Mitochondrial Turnover - drug effects Molecular and cellular biology Phenylbutyrates - therapeutic use Proteome - genetics Proteome - metabolism Small Molecule Libraries - therapeutic use Thiocyanates - therapeutic use
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