The Evi1, microRNA-143, K-Ras axis in colon cancer
MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown...
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| Veröffentlicht in: | FEBS letters 2011-02, Vol.585 (4), p.693-699 |
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| container_title | FEBS letters |
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| creator | Gao, Jin-Song Zhang, Yingjie Tang, Xiaoli Tucker, Lynne D. Tarwater, Patrick M. Quesenberry, Peter J. Rigoutsos, Isidore Ramratnam, Bharat |
| description | MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer. |
| doi_str_mv | 10.1016/j.febslet.2011.01.033 |
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For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2011.01.033</identifier><identifier>PMID: 21276449</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>3' Untranslated Regions ; Biomarkers, Tumor - metabolism ; Cell Line, Tumor ; Cell Migration Assays ; Colon cancer ; Colonic Neoplasms - metabolism ; colorectal neoplasms ; DNA Mutational Analysis ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; etiology ; Evi1 ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; HEK293 Cells ; Humans ; MDS1 and EVI1 Complex Locus Protein ; MicroRNA ; MicroRNAs - chemistry ; MicroRNAs - genetics ; MicroRNAs - metabolism ; oncogene proteins ; oncogenes ; Point Mutation ; Proto-Oncogene Proteins p21(ras) - genetics ; Proto-Oncogene Proteins p21(ras) - metabolism ; Proto-Oncogenes - genetics ; RNA Interference ; RNA, Messenger - metabolism ; Signal Transduction ; Tissue Banks ; transcription (genetics) ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transfection</subject><ispartof>FEBS letters, 2011-02, Vol.585 (4), p.693-699</ispartof><rights>2011 Federation of European Biochemical Societies</rights><rights>FEBS Letters 585 (2011) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><rights>2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6629-a7626fbbb65cd4a327fe3e394fbd1b251e2cc536ed7029cc2a48b0bb5b6b28023</citedby><cites>FETCH-LOGICAL-c6629-a7626fbbb65cd4a327fe3e394fbd1b251e2cc536ed7029cc2a48b0bb5b6b28023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2011.01.033$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579311000639$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,3537,27903,27904,45553,45554,46387,46811,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21276449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Jin-Song</creatorcontrib><creatorcontrib>Zhang, Yingjie</creatorcontrib><creatorcontrib>Tang, Xiaoli</creatorcontrib><creatorcontrib>Tucker, Lynne D.</creatorcontrib><creatorcontrib>Tarwater, Patrick M.</creatorcontrib><creatorcontrib>Quesenberry, Peter J.</creatorcontrib><creatorcontrib>Rigoutsos, Isidore</creatorcontrib><creatorcontrib>Ramratnam, Bharat</creatorcontrib><title>The Evi1, microRNA-143, K-Ras axis in colon cancer</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.</description><subject>3' Untranslated Regions</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Migration Assays</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - metabolism</subject><subject>colorectal neoplasms</subject><subject>DNA Mutational Analysis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>etiology</subject><subject>Evi1</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes, Reporter</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>MDS1 and EVI1 Complex Locus Protein</subject><subject>MicroRNA</subject><subject>MicroRNAs - chemistry</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>oncogene proteins</subject><subject>oncogenes</subject><subject>Point Mutation</subject><subject>Proto-Oncogene Proteins p21(ras) - genetics</subject><subject>Proto-Oncogene Proteins p21(ras) - metabolism</subject><subject>Proto-Oncogenes - genetics</subject><subject>RNA Interference</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction</subject><subject>Tissue Banks</subject><subject>transcription (genetics)</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transfection</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkFv1DAQhS0EotvCTwDlBodm8XhsJ7mASrWliAqkUs6W7UyoV9mk2Ltb-u9xtEsFF4o0sjXy86dnv2HsBfA5cNBvlvOOXOppPRccYM5zIT5iM6grLFHq-jGbcQ6yVFWDB-wwpSXPfQ3NU3YgQFRaymbGxNU1FYttgONiFXwcLz-flCDxuPhUXtpU2J8hFWEo_NiPebWDp_iMPelsn-j5fj9i384WV6fn5cWXDx9PTy5Kr7VoSltpoTvnnFa-lRZF1RESNrJzLTihgIT3CjW1FReN98LK2nHnlNNO1FzgEXu7495s3IpaT8M62t7cxLCy8c6MNpi_T4Zwbb6PW4NS8lrLDHi1B8Txx4bS2qxC8tT3dqBxk0zDK1C8kfigslbQoNI4MV__UwkVopJScJWlaifN35pSpO7eOnAzZWiWZp-hmTI0PBdOZl7--e77W79Dy4LzneA29HT3f1Rztngvvk4DMc0DQJ4FjRPq3Q5FOchtoGiSD5RTbkMkvzbtGB5w-ws-88J8</recordid><startdate>20110218</startdate><enddate>20110218</enddate><creator>Gao, Jin-Song</creator><creator>Zhang, Yingjie</creator><creator>Tang, Xiaoli</creator><creator>Tucker, Lynne D.</creator><creator>Tarwater, Patrick M.</creator><creator>Quesenberry, Peter J.</creator><creator>Rigoutsos, Isidore</creator><creator>Ramratnam, Bharat</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20110218</creationdate><title>The Evi1, microRNA-143, K-Ras axis in colon cancer</title><author>Gao, Jin-Song ; 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| ispartof | FEBS letters, 2011-02, Vol.585 (4), p.693-699 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 3' Untranslated Regions Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Migration Assays Colon cancer Colonic Neoplasms - metabolism colorectal neoplasms DNA Mutational Analysis DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism etiology Evi1 Gene Expression Regulation, Neoplastic Genes, Reporter HEK293 Cells Humans MDS1 and EVI1 Complex Locus Protein MicroRNA MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - metabolism oncogene proteins oncogenes Point Mutation Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Proto-Oncogenes - genetics RNA Interference RNA, Messenger - metabolism Signal Transduction Tissue Banks transcription (genetics) Transcription Factors - genetics Transcription Factors - metabolism Transfection |
| title | The Evi1, microRNA-143, K-Ras axis in colon cancer |
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