Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate

During proteinuria, renal tubular epithelial cells become exposed to ultrafiltrate-derived serum proteins, including complement factors. Recently, we showed that properdin binds to tubular heparan sulfates (HS). We now document that factor H also binds to tubular HS, although to a different epitope...

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Veröffentlicht in:	The Journal of biological chemistry 2012-09, Vol.287 (37), p.31471-31481
Hauptverfasser:	Zaferani, Azadeh, Vivès, Romain R., van der Pol, Pieter, Navis, Gerjan J., Daha, Mohamed R., van Kooten, Cees, Lortat-Jacob, Hugues, Seelen, Marc A., van den Born, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Cell Line Complement Factor H Complement Factor H - metabolism Complement System Epitopes Epitopes - metabolism Glycobiology and Extracellular Matrices Heparan Sulfate Heparitin Sulfate Heparitin Sulfate - metabolism Humans Inflammation Kidney Kidney Tubules Kidney Tubules - metabolism Kidney Tubules - pathology Life Sciences Male Properdin Properdin - metabolism Protein Binding Proteinuria Proteinuria - metabolism Proteinuria - mortality Proteoglycan Rats Rats, Wistar
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