Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation
Eukaryotic genomes are organized into higher order chromatin architectures by protein-mediated long-range interactions in the nucleus. CCCTC-binding factor (CTCF), a sequence-specific transcription factor, serves as a chromatin organizer in building this complex chromatin structure by linking chromo...
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| Veröffentlicht in: | The Journal of biological chemistry 2012-09, Vol.287 (37), p.30906-30913 |
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| container_title | The Journal of biological chemistry |
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| creator | Lee, Bum-Kyu Iyer, Vishwanath R. |
| description | Eukaryotic genomes are organized into higher order chromatin architectures by protein-mediated long-range interactions in the nucleus. CCCTC-binding factor (CTCF), a sequence-specific transcription factor, serves as a chromatin organizer in building this complex chromatin structure by linking chromosomal domains. Recent genome-wide studies mapping the binding sites of CTCF and its interacting partner, cohesin, using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) revealded that CTCF globally co-localizes with cohesin. This partnership between CTCF and cohesin is emerging as a novel and perhaps pivotal aspect of gene regulatory mechanisms, in addition to playing a role in the organization of higher order chromatin architecture. |
| doi_str_mv | 10.1074/jbc.R111.324962 |
| format | Article |
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CCCTC-binding factor (CTCF), a sequence-specific transcription factor, serves as a chromatin organizer in building this complex chromatin structure by linking chromosomal domains. Recent genome-wide studies mapping the binding sites of CTCF and its interacting partner, cohesin, using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) revealded that CTCF globally co-localizes with cohesin. This partnership between CTCF and cohesin is emerging as a novel and perhaps pivotal aspect of gene regulatory mechanisms, in addition to playing a role in the organization of higher order chromatin architecture.</description><subject>CCCTC-Binding Factor</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Chromatin Immunoprecipitation (ChIP)</subject><subject>Chromatin Regulation</subject><subject>Chromosomal Proteins, Non-Histone - genetics</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>Chromosome Mapping - methods</subject><subject>Cohesin</subject><subject>Cohesins</subject><subject>CTCF</subject><subject>Functional Genomics</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genome-Wide Association Study</subject><subject>Humans</subject><subject>Minireviews</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Transcription Factors</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1v1DAQxS0EokvhzA35WA7Z-iNO1hckFHVLpUqgtkjcrIkz2XWVtYvtLOK_x8uWCg7MZaSZ995Y_hHylrMlZ219ft_b5Q3nfClFrRvxjCw4W8lKKv7tOVkwJnilhVqdkFcp3bNSteYvyYkQWgkh2wXZX6IPO6x-uAHpbZ4Hh4mGkXZdd9dVvfOD8xu6BptDpGdltn5PwQ-0C1tMztMvMewP1iuf3GabqfM50G4bww5yWd_mONs8R_xtusHNPJV58K_JixGmhG8e-yn5ur646z5V158vr7qP15Wta5krgEbpRtnRQottzxurR-hrZFwBgG4VoG0GAU1rgbGxbfnIFYNeIq_5qECekg_H3Ie53-Fg0ecIk3mIbgfxpwngzL8b77ZmE_ZG1nKlhSwBZ48BMXyfMWWzc8niNIHHMCfDmdRMqlXdFOn5UWpjSCni-HSGM3OgZQotc6BljrSK493fr3vS_8FTBPoowPJHe4fRJOvQWxxcRJvNENx_w38B7Vul0g</recordid><startdate>20120907</startdate><enddate>20120907</enddate><creator>Lee, Bum-Kyu</creator><creator>Iyer, Vishwanath R.</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120907</creationdate><title>Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation</title><author>Lee, Bum-Kyu ; 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| issn | 0021-9258 1083-351X |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | CCCTC-Binding Factor Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatin - genetics Chromatin - metabolism Chromatin Immunoprecipitation (ChIP) Chromatin Regulation Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome Mapping - methods Cohesin Cohesins CTCF Functional Genomics Gene Expression Regulation - physiology Genome-Wide Association Study Humans Minireviews Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors |
| title | Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation |
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