Trabecular Level Analysis of Bone Cement Augmentation: A Comparative Experimental and Finite Element Study
The representation of cement–augmented bone in finite element (FE) models of vertebrae following vertebroplasty remains a challenge, and the methods of the model validation are limited. The aim of this study was to create specimen-specific FE models of cement–augmented synthetic bone at the microsco...
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| Veröffentlicht in: | Annals of biomedical engineering 2012-10, Vol.40 (10), p.2168-2176 |
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| description | The representation of cement–augmented bone in finite element (FE) models of vertebrae following vertebroplasty remains a challenge, and the methods of the model validation are limited. The aim of this study was to create specimen-specific FE models of cement–augmented synthetic bone at the microscopic level, and to develop a new methodology to validate these models. An open cell polyurethane foam was used reduce drying effects and because of its similar structure to osteoporotic trabecular bone. Cylindrical specimens of the foam were augmented with PMMA cement. Each specimen was loaded to three levels of compression inside a micro-computed tomography (μCT) scanner and imaged both before compression and in each of the loaded states. Micro-FE models were generated from the unloaded μCT images and displacements applied to match measurements taken from the images. A morphological comparison between the FE-predicted trabecular deformations and the corresponding experimental measurements was developed to validate the accuracy of the FE model. The predicted deformation was found to be accurate (less than 12% error) in the elastic region. This method can now be used to evaluate real bone and different types of bone cements for different clinical situations. |
| doi_str_mv | 10.1007/s10439-012-0587-3 |
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A. ; Jin, Z. M. ; Wilcox, R. K.</creator><creatorcontrib>Zhao, Y. ; Robson Brown, K. A. ; Jin, Z. M. ; Wilcox, R. K.</creatorcontrib><description>The representation of cement–augmented bone in finite element (FE) models of vertebrae following vertebroplasty remains a challenge, and the methods of the model validation are limited. The aim of this study was to create specimen-specific FE models of cement–augmented synthetic bone at the microscopic level, and to develop a new methodology to validate these models. An open cell polyurethane foam was used reduce drying effects and because of its similar structure to osteoporotic trabecular bone. Cylindrical specimens of the foam were augmented with PMMA cement. Each specimen was loaded to three levels of compression inside a micro-computed tomography (μCT) scanner and imaged both before compression and in each of the loaded states. Micro-FE models were generated from the unloaded μCT images and displacements applied to match measurements taken from the images. A morphological comparison between the FE-predicted trabecular deformations and the corresponding experimental measurements was developed to validate the accuracy of the FE model. The predicted deformation was found to be accurate (less than 12% error) in the elastic region. This method can now be used to evaluate real bone and different types of bone cements for different clinical situations.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-012-0587-3</identifier><identifier>PMID: 22648574</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Bone and Bones - chemistry ; Bone and Bones - ultrastructure ; Bone Cements - chemistry ; Classical Mechanics ; Compressive Strength ; Computed tomography ; Elasticity ; Finite Element Analysis ; Humans ; Models, Biological ; Osteoporosis ; X-Ray Microtomography</subject><ispartof>Annals of biomedical engineering, 2012-10, Vol.40 (10), p.2168-2176</ispartof><rights>The Author(s) 2012</rights><rights>Biomedical Engineering Society 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-86ac5472e21d8a75843ea9de367ba545bc9059d4d843987d697000f2f2da68803</citedby><cites>FETCH-LOGICAL-c503t-86ac5472e21d8a75843ea9de367ba545bc9059d4d843987d697000f2f2da68803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-012-0587-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-012-0587-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22648574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Y.</creatorcontrib><creatorcontrib>Robson Brown, K. A.</creatorcontrib><creatorcontrib>Jin, Z. M.</creatorcontrib><creatorcontrib>Wilcox, R. K.</creatorcontrib><title>Trabecular Level Analysis of Bone Cement Augmentation: A Comparative Experimental and Finite Element Study</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>The representation of cement–augmented bone in finite element (FE) models of vertebrae following vertebroplasty remains a challenge, and the methods of the model validation are limited. The aim of this study was to create specimen-specific FE models of cement–augmented synthetic bone at the microscopic level, and to develop a new methodology to validate these models. An open cell polyurethane foam was used reduce drying effects and because of its similar structure to osteoporotic trabecular bone. Cylindrical specimens of the foam were augmented with PMMA cement. Each specimen was loaded to three levels of compression inside a micro-computed tomography (μCT) scanner and imaged both before compression and in each of the loaded states. Micro-FE models were generated from the unloaded μCT images and displacements applied to match measurements taken from the images. A morphological comparison between the FE-predicted trabecular deformations and the corresponding experimental measurements was developed to validate the accuracy of the FE model. The predicted deformation was found to be accurate (less than 12% error) in the elastic region. This method can now be used to evaluate real bone and different types of bone cements for different clinical situations.</description><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Bone and Bones - chemistry</subject><subject>Bone and Bones - ultrastructure</subject><subject>Bone Cements - chemistry</subject><subject>Classical Mechanics</subject><subject>Compressive Strength</subject><subject>Computed tomography</subject><subject>Elasticity</subject><subject>Finite Element Analysis</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Osteoporosis</subject><subject>X-Ray Microtomography</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUtvEzEUhS0EomnhB7BBltiwmXI9frNAClEfSJFYUNaWM-MJEzl2sGei5t_X6ZSqVEJidWWf75577YPQOwLnBEB-ygQY1RWQugKuZEVfoBnhklZaKPESzQA0VEILdoJOc94AEKIof41O6lowxSWboc1NsivXjN4mvHR75_E8WH_Ifcaxw19jcHjhti4MeD6uj9UOfQyf8Rwv4nZnUznuHb643bnU38se29Diyz70Q7n3U--PYWwPb9Crzvrs3j7UM_Tz8uJmcV0tv199W8yXVcOBDpUStuFM1q4mrbKSK0ad1a2jQq4sZ3zVaOC6ZW0RtJKt0BIAurqrWyuUAnqGvky-u3G1dW1TFkjWm11Z0KaDibY3fyuh_2XWcW8oo4oBKQYfHwxS_D26PJhtnxvnvQ0ujtkQ0JQxroT-D5TqukQlaUE_PEM3cUzls-8ppQlwzgtFJqpJMefkuse9CZhj6GYK3ZTQzTF0c3R-__TBjx1_Ui5APQG5SGHt0tPR_3K9A577tvY</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Zhao, Y.</creator><creator>Robson Brown, K. 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A.</au><au>Jin, Z. M.</au><au>Wilcox, R. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trabecular Level Analysis of Bone Cement Augmentation: A Comparative Experimental and Finite Element Study</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>40</volume><issue>10</issue><spage>2168</spage><epage>2176</epage><pages>2168-2176</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>The representation of cement–augmented bone in finite element (FE) models of vertebrae following vertebroplasty remains a challenge, and the methods of the model validation are limited. The aim of this study was to create specimen-specific FE models of cement–augmented synthetic bone at the microscopic level, and to develop a new methodology to validate these models. An open cell polyurethane foam was used reduce drying effects and because of its similar structure to osteoporotic trabecular bone. Cylindrical specimens of the foam were augmented with PMMA cement. Each specimen was loaded to three levels of compression inside a micro-computed tomography (μCT) scanner and imaged both before compression and in each of the loaded states. Micro-FE models were generated from the unloaded μCT images and displacements applied to match measurements taken from the images. A morphological comparison between the FE-predicted trabecular deformations and the corresponding experimental measurements was developed to validate the accuracy of the FE model. The predicted deformation was found to be accurate (less than 12% error) in the elastic region. This method can now be used to evaluate real bone and different types of bone cements for different clinical situations.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22648574</pmid><doi>10.1007/s10439-012-0587-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Bone and Bones - chemistry Bone and Bones - ultrastructure Bone Cements - chemistry Classical Mechanics Compressive Strength Computed tomography Elasticity Finite Element Analysis Humans Models, Biological Osteoporosis X-Ray Microtomography |
| title | Trabecular Level Analysis of Bone Cement Augmentation: A Comparative Experimental and Finite Element Study |
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