Coiled Coils Ensure the Physiological Ectodomain Shedding of Collagen XVII

α-Helical coiled coils, frequent protein oligomerization motifs, are commonly observed in vital proteins. Here, using collagen XVII as an example, we provide evidence for a novel function of coiled coils in the regulation of ectodomain shedding. Transmembrane collagen XVII, an epithelial cell surfac...

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Veröffentlicht in:	The Journal of biological chemistry 2012-08, Vol.287 (35), p.29940-29948
Hauptverfasser:	Nishie, Wataru, Jackow, Joanna, Hofmann, Silke C., Franzke, Claus-Werner, Bruckner-Tuderman, Leena
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM ADAMTS Amino Acid Motifs Autoantigens - chemistry Autoantigens - genetics Autoantigens - metabolism Autoimmune Diseases Blister - genetics Blister - metabolism Collagen Collagen Type XVII Extracellular Matrix Proteins Furin Furin - chemistry Furin - genetics Furin - metabolism Humans Leucine Zipper Mass Spectrometry (MS) Metalloproteases - chemistry Metalloproteases - genetics Metalloproteases - metabolism Mutation Non-Fibrillar Collagens - chemistry Non-Fibrillar Collagens - genetics Non-Fibrillar Collagens - metabolism Protein Multimerization Protein Structure and Folding Protein Structure, Tertiary Skin - chemistry Skin - metabolism
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