Structure–Activity Relationships in Tripodal Transmembrane Anion Transporters: The Effect of Fluorination

A series of easy-to-make fluorinated tripodal anion transporters containing urea and thiourea groups have been prepared and their anion transport properties studied. Vesicle anion transport assays using ion-selective electrodes show that this class of compound is capable of transporting chloride thr...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-09, Vol.133 (35), p.14136-14148
Hauptverfasser:	Busschaert, Nathalie, Wenzel, Marco, Light, Mark E, Iglesias-Hernández, Paulina, Pérez-Tomás, Ricardo, Gale, Philip A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions - chemistry Anions - metabolism Binding Sites Cell Line, Tumor Cell Survival - drug effects Crystallography, X-Ray Halogenation Humans Ion Transport - drug effects Models, Molecular Structure-Activity Relationship Urea - analogs & derivatives Urea - pharmacology
Online-Zugang:	Volltext
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