Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers
AIM： To determine the pattern of secreted mucin expression in Helicobacter pylori （H. pylori）-related, nonsteroidal anti-inflammatory drug （NSAID）-related and idiopathic gastric ulcers. METHODS： We randomly selected 92 patients with H. pylori-associated （n = 30）, NSAID-associated （n = 18）, combined...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2012-09, Vol.18 (33), p.4597-4603 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Boltin, Doron Halpern, Marisa Levi, Zohar Vilkin, Alex Morgenstern, Sara Ho, Samuel B Niv, Yaron |
| description | AIM： To determine the pattern of secreted mucin expression in Helicobacter pylori （H. pylori）-related, nonsteroidal anti-inflammatory drug （NSAID）-related and idiopathic gastric ulcers. METHODS： We randomly selected 92 patients with H. pylori-associated （n = 30）, NSAID-associated （n = 18）, combined H. pylori and NSAID-associated gastric ulcers （n = 24）, and patients with idiopathic gastric ulcers （n = 20）. Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC （MUC5AC） and mucin 6 （MUC6）, was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS： MUC5AC was expressed on the surface epithelium （98.9%） and neck glands （98.9%） with minimal expression in the deep glands （6.5%）. MUC6 was strongly expressed in the deep glands （97.8%）, variable in the neck glands （19.6%） and absent in the surface epithelium （0%）. The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients （P = 0.009）. Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION： Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. |
| doi_str_mv | 10.3748/wjg.v18.i33.4597 |
| format | Article |
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METHODS： We randomly selected 92 patients with H. pylori-associated （n = 30）, NSAID-associated （n = 18）, combined H. pylori and NSAID-associated gastric ulcers （n = 24）, and patients with idiopathic gastric ulcers （n = 20）. Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC （MUC5AC） and mucin 6 （MUC6）, was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS： MUC5AC was expressed on the surface epithelium （98.9%） and neck glands （98.9%） with minimal expression in the deep glands （6.5%）. MUC6 was strongly expressed in the deep glands （97.8%）, variable in the neck glands （19.6%） and absent in the surface epithelium （0%）. The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients （P = 0.009）. Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION： Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v18.i33.4597</identifier><identifier>PMID: 22969235</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Brief ; CD4-CD8 Ratio ; Female ; Gastric Mucins - metabolism ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Helicobacter Infections - complications ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Mucin 5AC - metabolism ; Mucin-6 - metabolism ; T-Lymphocytes - pathology ; Ulcer - chemically induced ; Ulcer - metabolism ; Ulcer - microbiology ; Young Adult ; 免疫组织化学 ; 幽门螺旋杆菌 ; 物相 ; 粘蛋白 ; 胃溃疡 ; 菌相 ; 螺杆 ; 非甾体抗炎药</subject><ispartof>World journal of gastroenterology : WJG, 2012-09, Vol.18 (33), p.4597-4603</ispartof><rights>2012 Baishideng Publishing Group Co., Limited. All rights reserved. 2012</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-1066fb89beca54f3d774e34e058b8487e766dcfdeb223073b6eaf2c930b4905b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435787/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435787/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22969235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boltin, Doron</creatorcontrib><creatorcontrib>Halpern, Marisa</creatorcontrib><creatorcontrib>Levi, Zohar</creatorcontrib><creatorcontrib>Vilkin, Alex</creatorcontrib><creatorcontrib>Morgenstern, Sara</creatorcontrib><creatorcontrib>Ho, Samuel B</creatorcontrib><creatorcontrib>Niv, Yaron</creatorcontrib><title>Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To determine the pattern of secreted mucin expression in Helicobacter pylori （H. pylori）-related, nonsteroidal anti-inflammatory drug （NSAID）-related and idiopathic gastric ulcers. METHODS： We randomly selected 92 patients with H. pylori-associated （n = 30）, NSAID-associated （n = 18）, combined H. pylori and NSAID-associated gastric ulcers （n = 24）, and patients with idiopathic gastric ulcers （n = 20）. Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC （MUC5AC） and mucin 6 （MUC6）, was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS： MUC5AC was expressed on the surface epithelium （98.9%） and neck glands （98.9%） with minimal expression in the deep glands （6.5%）. MUC6 was strongly expressed in the deep glands （97.8%）, variable in the neck glands （19.6%） and absent in the surface epithelium （0%）. The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients （P = 0.009）. Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION： Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Brief</subject><subject>CD4-CD8 Ratio</subject><subject>Female</subject><subject>Gastric Mucins - metabolism</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucin 5AC - metabolism</subject><subject>Mucin-6 - metabolism</subject><subject>T-Lymphocytes - pathology</subject><subject>Ulcer - chemically induced</subject><subject>Ulcer - metabolism</subject><subject>Ulcer - microbiology</subject><subject>Young Adult</subject><subject>免疫组织化学</subject><subject>幽门螺旋杆菌</subject><subject>物相</subject><subject>粘蛋白</subject><subject>胃溃疡</subject><subject>菌相</subject><subject>螺杆</subject><subject>非甾体抗炎药</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1r3DAQxUVJaTZp7z0F515vZY1s2ZdACPkoBHppz0IfY6-CLTmSN8n2r6-WJEt7GmbmvTcwP0K-VnQNgrffnx-G9VPVrh3Amted-EBWjFVdyVpOj8iqolSUHTBxTE5SeqCUAdTsEzlmrGs6BvWK_LlVaYnOFNPWOF_gyxwxJRd8kbs7HJ0JWpkFYzHvxhBdGXFUC9pvhQ8-5XlwVo2F8osrne9HNU1qCXFX2Lgd3sV5bQtnXZjVssm3tqPBmD6Tj70aE355q6fk9831r6u78v7n7Y-ry_vScMaWsqJN0-u202hUzXuwQnAEjrRudctbgaJprOktasaACtANqp6ZDqjmHa01nJKL19x5qye0Bv0S1Sjn6CYVdzIoJ__feLeRQ3iSwKEWrcgB9DXAxJBSxP7grajcc5CZg8wcZOYg9xyy5ezfmwfD--Oz4PwtcxP88Oj8cNBwANhDg79DQJWR</recordid><startdate>20120907</startdate><enddate>20120907</enddate><creator>Boltin, Doron</creator><creator>Halpern, Marisa</creator><creator>Levi, Zohar</creator><creator>Vilkin, Alex</creator><creator>Morgenstern, Sara</creator><creator>Ho, Samuel B</creator><creator>Niv, Yaron</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20120907</creationdate><title>Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers</title><author>Boltin, Doron ; 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METHODS： We randomly selected 92 patients with H. pylori-associated （n = 30）, NSAID-associated （n = 18）, combined H. pylori and NSAID-associated gastric ulcers （n = 24）, and patients with idiopathic gastric ulcers （n = 20）. Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC （MUC5AC） and mucin 6 （MUC6）, was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS： MUC5AC was expressed on the surface epithelium （98.9%） and neck glands （98.9%） with minimal expression in the deep glands （6.5%）. MUC6 was strongly expressed in the deep glands （97.8%）, variable in the neck glands （19.6%） and absent in the surface epithelium （0%）. The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients （P = 0.009）. Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION： Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>22969235</pmid><doi>10.3748/wjg.v18.i33.4597</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - adverse effects Brief CD4-CD8 Ratio Female Gastric Mucins - metabolism Gastric Mucosa - metabolism Gastric Mucosa - pathology Helicobacter Infections - complications Helicobacter pylori Humans Male Middle Aged Mucin 5AC - metabolism Mucin-6 - metabolism T-Lymphocytes - pathology Ulcer - chemically induced Ulcer - metabolism Ulcer - microbiology Young Adult 免疫组织化学 幽门螺旋杆菌 物相 粘蛋白 胃溃疡 菌相 螺杆 非甾体抗炎药 |
| title | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers |
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