Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence

AIM： To investigate the prognostic value of CD44 variant 6 （CD44v6）, a membranous adhesion molecule, in rectal cancer. METHODS： Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy （RT, n = 90）, long-course （chemo） RT （n = 53） or surgery alone （n = 71） were...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2012-09, Vol.18 (33), p.4549-4556
1. Verfasser:	Avoranta, Suvi Tuulia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brief CD44 Cell Membrane - metabolism Cell Membrane - pathology Cell Proliferation Combined Modality Therapy Cytoplasm - metabolism Cytoplasm - pathology Female Gene Expression Regulation, Neoplastic - genetics Genetic Variation - genetics Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Male Middle Aged Neoplasm Grading Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Rectal Neoplasms - genetics Rectal Neoplasms - metabolism Rectal Neoplasms - pathology Retrospective Studies Risk Factors Sensitivity and Specificity Survival Rate 入侵变异体复发手术治疗早期直肠癌联营
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