PV1 down‐regulation via shRNA inhibits the growth of pancreatic adenocarcinoma xenografts

PV1 is an endothelial‐specific protein with structural roles in the formation of diaphragms in endothelial cells of normal vessels. PV1 is also highly expressed on endothelial cells of many solid tumours. On the basis of in vitro data, PV1 is thought to actively participate in angiogenesis. To test...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2012-11, Vol.16 (11), p.2690-2700
Hauptverfasser:	Deharvengt, Sophie J., Tse, Dan, Sideleva, Olga, McGarry, Caitlin, Gunn, Jason R., Longnecker, Daniel S., Carriere, Catherine, Stan, Radu V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - genetics Adenocarcinoma - pathology angiogenesis Animals Base Sequence Carrier Proteins - genetics Carrier Proteins - metabolism caveolae Cell Line, Tumor Cell Movement - genetics Down-Regulation Drug Screening Assays, Antitumor Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Female fenestrae Gene Expression Regulation, Neoplastic Humans Lentivirus - genetics Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Mice, Nude Molecular Sequence Data Neovascularization, Pathologic - genetics Original Pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA, Small Interfering - pharmacology Stromal Cells - metabolism Stromal Cells - pathology transendothelial channels tumour microenvironment vesiculo‐vacuolar organelles
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