The effects of 5-fluoruracil treatment on 3′-fluoro-3′-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells

Abstract 3′-Fluoro-3′-deoxythymidine (FLT) positron emission tomography (PET) has been proposed for imaging thymidylate synthase (TS) inhibition. Agents that target TS and shut down de novo synthesis of thymidine monophosphate increase the uptake and retention of FLT in vitro and in vivo because of...

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Veröffentlicht in:	Nuclear medicine and biology 2012-10, Vol.39 (7), p.970-976
Hauptverfasser:	Plotnik, David A, McLaughlin, Lena J, Krohn, Kenneth A, Schwartz, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Biological Transport - drug effects Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Dideoxynucleosides - metabolism ENT1 FLT-PET Imaging Fluorouracil - pharmacology Humans Medical sciences Nucleoside Metabolism Pharmacology. Drug treatments Radiology Thymidine Kinase - metabolism
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