Aging perturbs 26S proteasome assembly in Drosophila melanogaster

Aging is associated with loss of quality control in protein turnover. The ubiquitin-proteasome pathway is critical to this quality control process as it degrades mutated and damaged proteins. We identified a unique aging-dependent mechanism that contributes to proteasome dysfunction in Drosophila me...

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Veröffentlicht in:	The FASEB journal 2007-09, Vol.21 (11), p.2672-2682
Hauptverfasser:	Vernace, Vita A, Arnaud, Lisette, Schmidt-Glenewinkel, Thomas, Figueiredo-Pereira, Maria E
Format:	Artikel
Sprache:	eng
Schlagworte:	26S/20S protea‐somes Adenosine Triphosphate - metabolism Aging - physiology Animals ATP depletion Blotting, Western Cytosol - enzymology Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Female fly aging Male Proteasome Endopeptidase Complex - metabolism protein degradation Time Factors ubiquitin
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