Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues

There is biochemical, imaging and functional evidence that Rho GTPase signaling is a crucial regulator of actin-based structures such as lamellipodia and filopodia. However, although Rho GTPases are believed to serve similar functions in growth cones, the spatiotemporal dynamics of Rho GTPase signal...

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Veröffentlicht in:	Journal of cell science 2012-06, Vol.125 (Pt 12), p.2918-2929
Hauptverfasser:	Myers, Jonathan P, Robles, Estuardo, Ducharme-Smith, Allison, Gomez, Timothy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - enzymology Axons - metabolism Brain-Derived Neurotrophic Factor - metabolism cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell Movement Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Growth Cones - enzymology Growth Cones - metabolism Humans Laminin - metabolism Signal Transduction Xenopus laevis
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