Rapamycin slows aging in mice

Summary Rapamycin increases lifespan in mice, but whether this represents merely inhibition of lethal neoplastic diseases, or an overall slowing in multiple aspects of aging is currently unclear. We report here that many forms of age‐dependent change, including alterations in heart, liver, adrenal g...

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Veröffentlicht in:	Aging cell 2012-08, Vol.11 (4), p.675-682
Hauptverfasser:	Wilkinson, John E., Burmeister, Lisa, Brooks, Susan V., Chan, Chi‐Chao, Friedline, Sabrina, Harrison, David E., Hejtmancik, James F., Nadon, Nancy, Strong, Randy, Wood, Lauren K., Woodward, Maria A., Miller, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - chemically induced Aging Aging - drug effects Aging - pathology Aging - physiology Animals Cataract - chemically induced Endometrium - drug effects Endometrium - pathology Female interventions Liver - drug effects Liver - pathology Longevity - drug effects Longevity - physiology longevity pathology Male Medical research Mice Mice, 129 Strain Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Motor Activity - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Organ Specificity Rodents Sirolimus - blood Sirolimus - pharmacology Sirolimus - toxicity Tendons - drug effects Tendons - pathology Testis - drug effects Testis - pathology TOR TOR Serine-Threonine Kinases - antagonists & inhibitors
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