Rapamycin slows aging in mice

Summary Rapamycin increases lifespan in mice, but whether this represents merely inhibition of lethal neoplastic diseases, or an overall slowing in multiple aspects of aging is currently unclear. We report here that many forms of age‐dependent change, including alterations in heart, liver, adrenal g...

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Veröffentlicht in:Aging cell 2012-08, Vol.11 (4), p.675-682
Hauptverfasser: Wilkinson, John E., Burmeister, Lisa, Brooks, Susan V., Chan, Chi‐Chao, Friedline, Sabrina, Harrison, David E., Hejtmancik, James F., Nadon, Nancy, Strong, Randy, Wood, Lauren K., Woodward, Maria A., Miller, Richard A.
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container_end_page 682
container_issue 4
container_start_page 675
container_title Aging cell
container_volume 11
creator Wilkinson, John E.
Burmeister, Lisa
Brooks, Susan V.
Chan, Chi‐Chao
Friedline, Sabrina
Harrison, David E.
Hejtmancik, James F.
Nadon, Nancy
Strong, Randy
Wood, Lauren K.
Woodward, Maria A.
Miller, Richard A.
description Summary Rapamycin increases lifespan in mice, but whether this represents merely inhibition of lethal neoplastic diseases, or an overall slowing in multiple aspects of aging is currently unclear. We report here that many forms of age‐dependent change, including alterations in heart, liver, adrenal glands, endometrium, and tendon, as well as age‐dependent decline in spontaneous activity, occur more slowly in rapamycin‐treated mice, suggesting strongly that rapamycin retards multiple aspects of aging in mice, in addition to any beneficial effects it may have on neoplastic disease. We also note, however, that mice treated with rapamycin starting at 9 months of age have significantly higher incidence of testicular degeneration and cataracts; harmful effects of this kind will guide further studies on timing, dosage, and tissue‐specific actions of rapamycin relevant to the development of clinically useful inhibitors of TOR action.
doi_str_mv 10.1111/j.1474-9726.2012.00832.x
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We report here that many forms of age‐dependent change, including alterations in heart, liver, adrenal glands, endometrium, and tendon, as well as age‐dependent decline in spontaneous activity, occur more slowly in rapamycin‐treated mice, suggesting strongly that rapamycin retards multiple aspects of aging in mice, in addition to any beneficial effects it may have on neoplastic disease. We also note, however, that mice treated with rapamycin starting at 9 months of age have significantly higher incidence of testicular degeneration and cataracts; harmful effects of this kind will guide further studies on timing, dosage, and tissue‐specific actions of rapamycin relevant to the development of clinically useful inhibitors of TOR action.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/j.1474-9726.2012.00832.x</identifier><identifier>PMID: 22587563</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenal Gland Neoplasms - chemically induced ; Aging ; Aging - drug effects ; Aging - pathology ; Aging - physiology ; Animals ; Cataract - chemically induced ; Endometrium - drug effects ; Endometrium - pathology ; Female ; interventions ; Liver - drug effects ; Liver - pathology ; Longevity - drug effects ; Longevity - physiology ; longevity pathology ; Male ; Medical research ; Mice ; Mice, 129 Strain ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Motor Activity - drug effects ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - pathology ; Organ Specificity ; Rodents ; Sirolimus - blood ; Sirolimus - pharmacology ; Sirolimus - toxicity ; Tendons - drug effects ; Tendons - pathology ; Testis - drug effects ; Testis - pathology ; TOR ; TOR Serine-Threonine Kinases - antagonists &amp; inhibitors</subject><ispartof>Aging cell, 2012-08, Vol.11 (4), p.675-682</ispartof><rights>2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland</rights><rights>2012 The Authors. 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We report here that many forms of age‐dependent change, including alterations in heart, liver, adrenal glands, endometrium, and tendon, as well as age‐dependent decline in spontaneous activity, occur more slowly in rapamycin‐treated mice, suggesting strongly that rapamycin retards multiple aspects of aging in mice, in addition to any beneficial effects it may have on neoplastic disease. 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subjects Adrenal Gland Neoplasms - chemically induced
Aging
Aging - drug effects
Aging - pathology
Aging - physiology
Animals
Cataract - chemically induced
Endometrium - drug effects
Endometrium - pathology
Female
interventions
Liver - drug effects
Liver - pathology
Longevity - drug effects
Longevity - physiology
longevity pathology
Male
Medical research
Mice
Mice, 129 Strain
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Motor Activity - drug effects
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - pathology
Organ Specificity
Rodents
Sirolimus - blood
Sirolimus - pharmacology
Sirolimus - toxicity
Tendons - drug effects
Tendons - pathology
Testis - drug effects
Testis - pathology
TOR
TOR Serine-Threonine Kinases - antagonists & inhibitors
title Rapamycin slows aging in mice
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