The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress

Falcarindiol (FAD) is a natural polyyne with various beneficial biological activities. We show here that FAD preferentially kills colon cancer cells but not normal colon epithelial cells. Furthermore, FAD inhibits tumor growth in a xenograft tumor model and exhibits strong synergistic killing of can...

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Veröffentlicht in:	Cell death & disease 2012-08, Vol.3 (8), p.e376-e376
Hauptverfasser:	Jin, H R, Zhao, J, Zhang, Z, Liao, Y, Wang, C-Z, Huang, W-H, Li, S-P, He, T-C, Yuan, C-S, Du, W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/349 631/92/609 692/699/67/1059/153 692/699/67/1504/1885/1393 Animals Antibodies Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic Agents, Phytogenic - toxicity Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell death Cell Line, Tumor Colorectal Neoplasms - drug therapy Diynes - therapeutic use Diynes - toxicity Drug Synergism Endoplasmic Reticulum Stress - drug effects Fatty Alcohols - therapeutic use Fatty Alcohols - toxicity Fluorouracil - toxicity HCT116 Cells Heat-Shock Proteins - antagonists & inhibitors Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Immunology Life Sciences Mice Original original-article Transplantation, Heterologous Ubiquitination - drug effects Unfolded Protein Response - drug effects
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