Increase of 20-HETE Synthase after Brain Ischemia in Rats Revealed by PET Study with 11C-Labeled 20-HETE Synthase-Specific Inhibitor

20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite known to be produced after cerebral ischemia, has been implicated in ischemic and reperfusion injury by mediating vasoconstriction. To develop a positron emission tomography (PET) probe for 20-HETE synthase imaging, which migh...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-09, Vol.32 (9), p.1737-1746
Hauptverfasser:	Kawasaki, Toshiyuki, Marumo, Toshiyuki, Shirakami, Keiko, Mori, Tomoko, Doi, Hisashi, Suzuki, Masaaki, Watanabe, Yasuyoshi, Chaki, Shigeyuki, Nakazato, Atsuro, Ago, Yukio, Hashimoto, Hitoshi, Matsuda, Toshio, Baba, Akemichi, Onoe, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Brain Ischemia - diagnostic imaging Brain Ischemia - enzymology Carbon Radioisotopes Cytochrome P-450 CYP4A - antagonists & inhibitors Cytochrome P-450 CYP4A - biosynthesis Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacokinetics Enzyme-Linked Immunosorbent Assay Hydroxyeicosatetraenoic Acids - metabolism Imidazoles - pharmacology Immunohistochemistry Isotope Labeling Longitudinal Studies Medical sciences Mice Mice, Inbred C57BL Neurology Neuropharmacology Neuroprotective agent Original Pharmacology. Drug treatments Polymerase Chain Reaction Positron-Emission Tomography Radiopharmaceuticals - chemical synthesis Rats Rats, Wistar Tissue Distribution Vascular diseases and vascular malformations of the nervous system
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