Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

Relocalization of proteins is a hallmark of the DNA damage response. We use high-throughput microscopic screening of the yeast GFP fusion collection to develop a systems-level view of protein reorganization following drug-induced DNA replication stress. Changes in protein localization and abundance...

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Veröffentlicht in:	Nature cell biology 2012-09, Vol.14 (9), p.966-976
Hauptverfasser:	Tkach, Johnny M., Yimit, Askar, Lee, Anna Y., Riffle, Michael, Costanzo, Michael, Jaschob, Daniel, Hendry, Jason A., Ou, Jiongwen, Moffat, Jason, Boone, Charles, Davis, Trisha N., Nislow, Corey, Brown, Grant W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2163 631/337/1427/2566 631/80/641/151 Adaptor Proteins, Signal Transducing - metabolism Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cellular proteins Deoxyribonucleic acid Developmental Biology DNA DNA Damage DNA replication DNA Replication - genetics DNA Replication - physiology DNA-Binding Proteins - metabolism Gene Deletion GTP-Binding Proteins - metabolism Histone Deacetylases - metabolism Intracellular Signaling Peptides and Proteins - metabolism Kinases Life Sciences Localization Phosphorylation Physiological aspects Protein Transport - genetics Protein Transport - physiology Protein-Serine-Threonine Kinases - metabolism Proteins resource Ribonucleotide reductase Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - metabolism Sequence Deletion Stem Cells Yeast Yeasts
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