Interplay of Genetic Risk Factors (CHRNA5-CHRNA3-CHRNB4) and Cessation Treatments in Smoking Cessation Success

When smokers were separated by their nicotinic receptor gene variants, those with the low-risk genotype responded equally well to pharmacological treatments, including both nicotine replacement and bupropion, and nonpharmacological therapies. Those with the high-risk genotype, as identified by DNA s...

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Veröffentlicht in:	The American journal of psychiatry 2012-07, Vol.169 (7), p.735-742
Hauptverfasser:	Chen, Li-Shiun, Baker, Timothy B., Piper, Megan E., Breslau, Naomi, Cannon, Dale S., Doheny, Kimberly F., Gogarten, Stephanie M., Johnson, Eric O., Saccone, Nancy L., Wang, Jen C., Weiss, Robert B., Goate, Alison M., Bierut, Laura Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adult and adolescent clinical studies Age Factors Behavior modification Biological and medical sciences Clinical Trials as Topic - statistics & numerical data Desintoxication. Drug withdrawal Female Genetic markers Haplotypes Humans Male Medical sciences Middle Aged Nerve Tissue Proteins - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Nicotinic - genetics Risk Factors Smoking cessation Smoking Cessation - methods Tobacco smoking Tobacco Use Disorder - drug therapy Tobacco Use Disorder - genetics Tobacco, tobacco smoking Toxicology Treatments
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