Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer
Abstract A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased...
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| Veröffentlicht in: | Cancer letters 2010-06, Vol.292 (2), p.176-185 |
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| container_title | Cancer letters |
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| creator | Chiu, Helen H.L Yong, Theresa M.K Wang, Jun Wang, Yuwei Vessella, Robert L Ueda, Takeshi Wang, Yu-Zhuo Sadar, Marianne D |
| description | Abstract A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-κB that physically associated to previously uncharacterized κB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased ( p = 0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration. |
| doi_str_mv | 10.1016/j.canlet.2009.11.023 |
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Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-κB that physically associated to previously uncharacterized κB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased ( p = 0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2009.11.023</identifier><identifier>PMID: 20044205</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Androgen deprivation ; Androgens - metabolism ; Apoptosis ; Blotting, Western ; Castration ; Chromatin Immunoprecipitation ; Genes ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Inhibitors of apoptosis ; Kinases ; Male ; Neuronal apoptosis inhibitory protein ; Neuronal Apoptosis-Inhibitory Protein - genetics ; Neuronal Apoptosis-Inhibitory Protein - metabolism ; NF-kappa B - metabolism ; Nuclear factor-κB ; Prostate cancer ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; Rodents</subject><ispartof>Cancer letters, 2010-06, Vol.292 (2), p.176-185</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>Copyright 2009 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 28, 2010</rights><rights>2009 Elsevier Ireland Ltd. All rights reserved. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-3b44fbb15d6f824b2e952c8e01c5f06fe0a911a3b9140b6642608e94e0f429ce3</citedby><cites>FETCH-LOGICAL-c643t-3b44fbb15d6f824b2e952c8e01c5f06fe0a911a3b9140b6642608e94e0f429ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2009.11.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20044205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiu, Helen H.L</creatorcontrib><creatorcontrib>Yong, Theresa M.K</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Wang, Yuwei</creatorcontrib><creatorcontrib>Vessella, Robert L</creatorcontrib><creatorcontrib>Ueda, Takeshi</creatorcontrib><creatorcontrib>Wang, Yu-Zhuo</creatorcontrib><creatorcontrib>Sadar, Marianne D</creatorcontrib><title>Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-κB that physically associated to previously uncharacterized κB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased ( p = 0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.</description><subject>Androgen deprivation</subject><subject>Androgens - metabolism</subject><subject>Apoptosis</subject><subject>Blotting, Western</subject><subject>Castration</subject><subject>Chromatin Immunoprecipitation</subject><subject>Genes</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inhibitors of apoptosis</subject><subject>Kinases</subject><subject>Male</subject><subject>Neuronal apoptosis inhibitory protein</subject><subject>Neuronal Apoptosis-Inhibitory Protein - genetics</subject><subject>Neuronal Apoptosis-Inhibitory Protein - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>Nuclear factor-κB</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Rodents</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAUjBCILoV_gFAkDpyyPH9ufEFCFR-VKnEAzpbjvLResnawnVX33-NolxZ6qXywLc-M35t5VfWawJoAke-3a2v8iHlNAdSakDVQ9qRakXZDm41q4Wm1Aga8YS0TZ9WLlLYAIPhGPK_OCoVzCmJV5Uvfzza74Osw1B7nGLwZazOFKYfkUu38jetcDvFQTzFkdL7G2yliSgun3MpxCj5hnUNtfB_DNfq6xym6vcknTGGmbDLWpWSL8WX1bDBjwlen_bz6-fnTj4uvzdW3L5cXH68aKznLDes4H7qOiF4OLeUdRSWobRGIFQPIAcEoQgzrFOHQScmphBYVRxg4VRbZefXhqDvN3Q57iz5HM-pS2s7Egw7G6f9fvLvR12GvGWeMKVkE3p0EYvg9Y8p655LFcTQew5z0hkuAUhp9HMmYUEwJVpBvHyC3YY7F9KSJAFkWk4seP6JssS5FHO6qJqCX_PVWH_PXS_6aEF3yL7Q3_3Z8R_ob-L0lWHzfO4w6WYcllN5FtFn3wT32w0MBOzrvrBl_4QHTfS86UQ36-zKDywiCApCqGPsHNNXazQ</recordid><startdate>20100628</startdate><enddate>20100628</enddate><creator>Chiu, Helen H.L</creator><creator>Yong, Theresa M.K</creator><creator>Wang, Jun</creator><creator>Wang, Yuwei</creator><creator>Vessella, Robert L</creator><creator>Ueda, Takeshi</creator><creator>Wang, Yu-Zhuo</creator><creator>Sadar, Marianne D</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100628</creationdate><title>Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer</title><author>Chiu, Helen H.L ; Yong, Theresa M.K ; Wang, Jun ; Wang, Yuwei ; Vessella, Robert L ; Ueda, Takeshi ; Wang, Yu-Zhuo ; Sadar, Marianne D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-3b44fbb15d6f824b2e952c8e01c5f06fe0a911a3b9140b6642608e94e0f429ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Androgen deprivation</topic><topic>Androgens - metabolism</topic><topic>Apoptosis</topic><topic>Blotting, Western</topic><topic>Castration</topic><topic>Chromatin Immunoprecipitation</topic><topic>Genes</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inhibitors of apoptosis</topic><topic>Kinases</topic><topic>Male</topic><topic>Neuronal apoptosis inhibitory protein</topic><topic>Neuronal Apoptosis-Inhibitory Protein - genetics</topic><topic>Neuronal Apoptosis-Inhibitory Protein - metabolism</topic><topic>NF-kappa B - metabolism</topic><topic>Nuclear factor-κB</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiu, Helen H.L</creatorcontrib><creatorcontrib>Yong, Theresa M.K</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Wang, Yuwei</creatorcontrib><creatorcontrib>Vessella, Robert L</creatorcontrib><creatorcontrib>Ueda, Takeshi</creatorcontrib><creatorcontrib>Wang, Yu-Zhuo</creatorcontrib><creatorcontrib>Sadar, Marianne D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiu, Helen H.L</au><au>Yong, Theresa M.K</au><au>Wang, Jun</au><au>Wang, Yuwei</au><au>Vessella, Robert L</au><au>Ueda, Takeshi</au><au>Wang, Yu-Zhuo</au><au>Sadar, Marianne D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2010-06-28</date><risdate>2010</risdate><volume>292</volume><issue>2</issue><spage>176</spage><epage>185</epage><pages>176-185</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-κB that physically associated to previously uncharacterized κB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased ( p = 0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20044205</pmid><doi>10.1016/j.canlet.2009.11.023</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer letters, 2010-06, Vol.292 (2), p.176-185 |
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| subjects | Androgen deprivation Androgens - metabolism Apoptosis Blotting, Western Castration Chromatin Immunoprecipitation Genes Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Inhibitors of apoptosis Kinases Male Neuronal apoptosis inhibitory protein Neuronal Apoptosis-Inhibitory Protein - genetics Neuronal Apoptosis-Inhibitory Protein - metabolism NF-kappa B - metabolism Nuclear factor-κB Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents |
| title | Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer |
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