Cofactor-Mediated Restriction of GATA-1 Chromatin Occupancy Coordinates Lineage-Specific Gene Expression

GATA-1 and its cofactor FOG-1 are required for the differentiation of erythrocytes and megakaryocytes. In contrast, mast cell development requires GATA-1 and the absence of FOG-1. Through genome-wide comparison of the chromatin occupancy of GATA-1 and a naturally occurring mutant that cannot bind FO...

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Veröffentlicht in:	Molecular cell 2012-08, Vol.47 (4), p.608-621
Hauptverfasser:	Chlon, Timothy M., Doré, Louis C., Crispino, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Binding Sites Cells, Cultured chromatin Chromatin - genetics Chromatin - metabolism Down-Regulation erythrocytes GATA transcription factors GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism gene expression gene expression regulation Gene Expression Regulation - genetics genes mast cells Mast Cells - metabolism megakaryocytes Mice Mice, Inbred C57BL mutants Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Proto-Oncogene Protein c-fli-1 - genetics Proto-Oncogene Protein c-fli-1 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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