Virotherapy using a novel chimeric oncolytic adenovirus prolongs survival in a human pancreatic cancer xenograft model

Introduction Pancreatic adenocarcinoma is an aggressive malignancy. Oncolytic adenoviruses (Ads) are modified genetically to target tumor cells while sparing normal cells. We modified the knob domain of the Ad serotype 5 with a serotype 3 knob domain and incorporated the CXCR4 promoter to regulate A...

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Veröffentlicht in:	Surgery 2012-09, Vol.152 (3), p.441-448
Hauptverfasser:	Chu, Quyen D., MD, FACS, Sun, Guang, BS, Pope, Matt, Luraguiz, Natalia, MD, Curiel, David T., MD, PhD, Kim, Roger, MD, Li, Benjamin D.L., MD, FACS, Mathis, J. Michael, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - therapy Adenocarcinoma - virology Analysis of Variance Animals Biological and medical sciences Cell Line, Tumor Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Kaplan-Meier Estimate Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, SCID Oncolytic Virotherapy - methods Oncolytic Viruses - classification Oncolytic Viruses - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - therapy Pancreatic Neoplasms - virology Rats Receptors, CXCR4 - metabolism Serotyping Surgery Tumor Burden Tumors Xenograft Model Antitumor Assays
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