Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress
Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor ( OXTR ) and brain-derived neurotrophic factor ( BDNF ). The cross sectiona...
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| Veröffentlicht in: | Translational psychiatry 2012-08, Vol.2 (8), p.e150-e150 |
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| creator | Unternaehrer, E Luers, P Mill, J Dempster, E Meyer, A H Staehli, S Lieb, R Hellhammer, D H Meinlschmidt, G |
| description | Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (
OXTR
) and brain-derived neurotrophic factor (
BDNF
). The cross sectional study took place at the Division of Theoretical and Clinical Psychobiology, University of Trier, Germany and was conducted from February to August 2009. We included 83 participants aged 61–67 years. Thereof, 76 participants completed the full study procedure consisting of blood sampling before (pre-stress), 10 min after (post-stress) and 90 min after (follow-up) the Trier social stress test. We assessed quantitative DNA methylation of whole-blood cells using Sequenom EpiTYPER. Methylation status differed between sampling times in one target sequence of
OXTR
(
P |
| doi_str_mv | 10.1038/tp.2012.77 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3432191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1033682234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-7bef7366bedb1deb377ad59b9bde4052608a3f30b20d5cfe9b4aa5ee2e41351a3</originalsourceid><addsrcrecordid>eNplkc1u1DAURi1ERatpNzwAssSmlGbwTxw7G6TSoQWpaiVUJHaW49zMpEri1HaQZtctr8mT4DJDNYA3tnSPz732h9BLSuaUcPUujnNGKJtL-QwdMCpUxqlSz3fO--gohDuSlsgVlfQF2mdMlUzS4gD1i_Vg-tZiuzLDEgJuB7y4PsM9xNW6M7F1A3YNDtFDCJkJwdnWRKjxEoZEH998u_1yij8sri9-Pvx4g00TwWNjpwh4DGu7cr8vdFvBIdprTBfgaLvP0NeLj7fnn7Krm8vP52dXmRVExUxW0EheFBXUFa2h4lKaWpRVWdWQE8EKogxvOKkYqYVtoKxyYwQAg5xyQQ2fofcb7zhVPdQWhuhNp0ff9savtTOt_rsytCu9dN81zzmjJU2C463Au_sJQtR9Gyx0nRnATUGnr-eFYizxM_T6H_TOTX5Iz9NUJlVJBBGJOtlQ1rsQPDRPw1DyaFM6jvoxSC1lgl_tjv-E_oktAW83QEilFJvf6fm_7hecV6jn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791390505</pqid></control><display><type>article</type><title>Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><creator>Unternaehrer, E ; Luers, P ; Mill, J ; Dempster, E ; Meyer, A H ; Staehli, S ; Lieb, R ; Hellhammer, D H ; Meinlschmidt, G</creator><creatorcontrib>Unternaehrer, E ; Luers, P ; Mill, J ; Dempster, E ; Meyer, A H ; Staehli, S ; Lieb, R ; Hellhammer, D H ; Meinlschmidt, G</creatorcontrib><description>Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (
OXTR
) and brain-derived neurotrophic factor (
BDNF
). The cross sectional study took place at the Division of Theoretical and Clinical Psychobiology, University of Trier, Germany and was conducted from February to August 2009. We included 83 participants aged 61–67 years. Thereof, 76 participants completed the full study procedure consisting of blood sampling before (pre-stress), 10 min after (post-stress) and 90 min after (follow-up) the Trier social stress test. We assessed quantitative DNA methylation of whole-blood cells using Sequenom EpiTYPER. Methylation status differed between sampling times in one target sequence of
OXTR
(
P
<0.001): methylation increased from pre- to post-stress (
P
=0.009) and decreased from post-stress to follow-up (
P
<0.001). This decrease was also found in a second target sequence of
OXTR
(
P
=0.034), where it lost statistical significance when blood cell count was statistically controlled. We did not detect any time-associated differences in methylation status of the examined
BDNF
region. The results suggest a dynamic regulation of DNA methylation in
OXTR
—which may in part reflect changes in blood cell composition—but not
BDNF
after acute psychosocial stress. This may enhance the understanding of how psychosocial events alter DNA methylation and could provide new insights into the etiology of mental disorders.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/tp.2012.77</identifier><identifier>PMID: 22892716</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/176/1988 ; 631/378/1689/1831 ; 631/378/2584 ; Aged ; Behavioral Sciences ; Biological Psychology ; Brain-Derived Neurotrophic Factor - blood ; Brain-Derived Neurotrophic Factor - genetics ; CpG Islands - genetics ; Cross-Sectional Studies ; DNA Methylation - genetics ; Epigenomics ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurosciences ; Original ; original-article ; Pharmacotherapy ; Psychiatry ; Receptors, Oxytocin - blood ; Receptors, Oxytocin - genetics ; Stress, Psychological - blood ; Stress, Psychological - genetics</subject><ispartof>Translational psychiatry, 2012-08, Vol.2 (8), p.e150-e150</ispartof><rights>The Author(s) 2012</rights><rights>Copyright Nature Publishing Group Aug 2012</rights><rights>Copyright © 2012 Macmillan Publishers Limited 2012 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-7bef7366bedb1deb377ad59b9bde4052608a3f30b20d5cfe9b4aa5ee2e41351a3</citedby><cites>FETCH-LOGICAL-c508t-7bef7366bedb1deb377ad59b9bde4052608a3f30b20d5cfe9b4aa5ee2e41351a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432191/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432191/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22892716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Unternaehrer, E</creatorcontrib><creatorcontrib>Luers, P</creatorcontrib><creatorcontrib>Mill, J</creatorcontrib><creatorcontrib>Dempster, E</creatorcontrib><creatorcontrib>Meyer, A H</creatorcontrib><creatorcontrib>Staehli, S</creatorcontrib><creatorcontrib>Lieb, R</creatorcontrib><creatorcontrib>Hellhammer, D H</creatorcontrib><creatorcontrib>Meinlschmidt, G</creatorcontrib><title>Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>Transl Psychiatry</addtitle><description>Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (
OXTR
) and brain-derived neurotrophic factor (
BDNF
). The cross sectional study took place at the Division of Theoretical and Clinical Psychobiology, University of Trier, Germany and was conducted from February to August 2009. We included 83 participants aged 61–67 years. Thereof, 76 participants completed the full study procedure consisting of blood sampling before (pre-stress), 10 min after (post-stress) and 90 min after (follow-up) the Trier social stress test. We assessed quantitative DNA methylation of whole-blood cells using Sequenom EpiTYPER. Methylation status differed between sampling times in one target sequence of
OXTR
(
P
<0.001): methylation increased from pre- to post-stress (
P
=0.009) and decreased from post-stress to follow-up (
P
<0.001). This decrease was also found in a second target sequence of
OXTR
(
P
=0.034), where it lost statistical significance when blood cell count was statistically controlled. We did not detect any time-associated differences in methylation status of the examined
BDNF
region. The results suggest a dynamic regulation of DNA methylation in
OXTR
—which may in part reflect changes in blood cell composition—but not
BDNF
after acute psychosocial stress. This may enhance the understanding of how psychosocial events alter DNA methylation and could provide new insights into the etiology of mental disorders.</description><subject>631/337/176/1988</subject><subject>631/378/1689/1831</subject><subject>631/378/2584</subject><subject>Aged</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>CpG Islands - genetics</subject><subject>Cross-Sectional Studies</subject><subject>DNA Methylation - genetics</subject><subject>Epigenomics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Receptors, Oxytocin - blood</subject><subject>Receptors, Oxytocin - genetics</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - genetics</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkc1u1DAURi1ERatpNzwAssSmlGbwTxw7G6TSoQWpaiVUJHaW49zMpEri1HaQZtctr8mT4DJDNYA3tnSPz732h9BLSuaUcPUujnNGKJtL-QwdMCpUxqlSz3fO--gohDuSlsgVlfQF2mdMlUzS4gD1i_Vg-tZiuzLDEgJuB7y4PsM9xNW6M7F1A3YNDtFDCJkJwdnWRKjxEoZEH998u_1yij8sri9-Pvx4g00TwWNjpwh4DGu7cr8vdFvBIdprTBfgaLvP0NeLj7fnn7Krm8vP52dXmRVExUxW0EheFBXUFa2h4lKaWpRVWdWQE8EKogxvOKkYqYVtoKxyYwQAg5xyQQ2fofcb7zhVPdQWhuhNp0ff9savtTOt_rsytCu9dN81zzmjJU2C463Au_sJQtR9Gyx0nRnATUGnr-eFYizxM_T6H_TOTX5Iz9NUJlVJBBGJOtlQ1rsQPDRPw1DyaFM6jvoxSC1lgl_tjv-E_oktAW83QEilFJvf6fm_7hecV6jn</recordid><startdate>20120814</startdate><enddate>20120814</enddate><creator>Unternaehrer, E</creator><creator>Luers, P</creator><creator>Mill, J</creator><creator>Dempster, E</creator><creator>Meyer, A H</creator><creator>Staehli, S</creator><creator>Lieb, R</creator><creator>Hellhammer, D H</creator><creator>Meinlschmidt, G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120814</creationdate><title>Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress</title><author>Unternaehrer, E ; Luers, P ; Mill, J ; Dempster, E ; Meyer, A H ; Staehli, S ; Lieb, R ; Hellhammer, D H ; Meinlschmidt, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-7bef7366bedb1deb377ad59b9bde4052608a3f30b20d5cfe9b4aa5ee2e41351a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/337/176/1988</topic><topic>631/378/1689/1831</topic><topic>631/378/2584</topic><topic>Aged</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>CpG Islands - genetics</topic><topic>Cross-Sectional Studies</topic><topic>DNA Methylation - genetics</topic><topic>Epigenomics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><topic>Receptors, Oxytocin - blood</topic><topic>Receptors, Oxytocin - genetics</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Unternaehrer, E</creatorcontrib><creatorcontrib>Luers, P</creatorcontrib><creatorcontrib>Mill, J</creatorcontrib><creatorcontrib>Dempster, E</creatorcontrib><creatorcontrib>Meyer, A H</creatorcontrib><creatorcontrib>Staehli, S</creatorcontrib><creatorcontrib>Lieb, R</creatorcontrib><creatorcontrib>Hellhammer, D H</creatorcontrib><creatorcontrib>Meinlschmidt, G</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Unternaehrer, E</au><au>Luers, P</au><au>Mill, J</au><au>Dempster, E</au><au>Meyer, A H</au><au>Staehli, S</au><au>Lieb, R</au><au>Hellhammer, D H</au><au>Meinlschmidt, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><addtitle>Transl Psychiatry</addtitle><date>2012-08-14</date><risdate>2012</risdate><volume>2</volume><issue>8</issue><spage>e150</spage><epage>e150</epage><pages>e150-e150</pages><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (
OXTR
) and brain-derived neurotrophic factor (
BDNF
). The cross sectional study took place at the Division of Theoretical and Clinical Psychobiology, University of Trier, Germany and was conducted from February to August 2009. We included 83 participants aged 61–67 years. Thereof, 76 participants completed the full study procedure consisting of blood sampling before (pre-stress), 10 min after (post-stress) and 90 min after (follow-up) the Trier social stress test. We assessed quantitative DNA methylation of whole-blood cells using Sequenom EpiTYPER. Methylation status differed between sampling times in one target sequence of
OXTR
(
P
<0.001): methylation increased from pre- to post-stress (
P
=0.009) and decreased from post-stress to follow-up (
P
<0.001). This decrease was also found in a second target sequence of
OXTR
(
P
=0.034), where it lost statistical significance when blood cell count was statistically controlled. We did not detect any time-associated differences in methylation status of the examined
BDNF
region. The results suggest a dynamic regulation of DNA methylation in
OXTR
—which may in part reflect changes in blood cell composition—but not
BDNF
after acute psychosocial stress. This may enhance the understanding of how psychosocial events alter DNA methylation and could provide new insights into the etiology of mental disorders.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22892716</pmid><doi>10.1038/tp.2012.77</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/337/176/1988 631/378/1689/1831 631/378/2584 Aged Behavioral Sciences Biological Psychology Brain-Derived Neurotrophic Factor - blood Brain-Derived Neurotrophic Factor - genetics CpG Islands - genetics Cross-Sectional Studies DNA Methylation - genetics Epigenomics Female Humans Male Medicine Medicine & Public Health Middle Aged Neurosciences Original original-article Pharmacotherapy Psychiatry Receptors, Oxytocin - blood Receptors, Oxytocin - genetics Stress, Psychological - blood Stress, Psychological - genetics |
| title | Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress |
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