Infant origins of childhood asthma associated with specific molds
Background The specific cause or causes of asthma development must be identified to prevent this disease. Objective Our hypothesis was that specific mold exposures are associated with childhood asthma development. Methods Infants were identified from birth certificates. Dust samples were collected f...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2012-09, Vol.130 (3), p.639-644.e5 |
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| creator | Reponen, Tiina, PhD Lockey, James, MD, MS Bernstein, David I., MD Vesper, Stephen J., PhD Levin, Linda, PhD Khurana Hershey, Gurjit K., MD, PhD Zheng, Shu, PhD Ryan, Patrick, PhD Grinshpun, Sergey A., PhD Villareal, Manuel, MD LeMasters, Grace, PhD |
| description | Background The specific cause or causes of asthma development must be identified to prevent this disease. Objective Our hypothesis was that specific mold exposures are associated with childhood asthma development. Methods Infants were identified from birth certificates. Dust samples were collected from 289 homes when the infants were 8 months of age. Samples were analyzed for concentrations of 36 molds that comprise the Environmental Relative Moldiness Index (ERMI) and endotoxin, house dust mite, cat, dog, and cockroach allergens. Children were evaluated at age 7 years for asthma based on reported symptoms and objective measures of lung function. Host, environmental exposure, and home characteristics evaluated included a history of parental asthma, race, sex, upper and lower respiratory tract symptoms, season of birth, family income, cigarette smoke exposure, air conditioning, use of a dehumidifier, presence of carpeting, age of home, and visible mold at age 1 year and child's positive skin prick test response to aeroallergens and molds at age 7 years. Results Asthma was diagnosed in 24% of the children at age 7 years. A statistically significant increase in asthma risk at age 7 years was associated with high ERMI values in the child's home in infancy (adjusted relative risk for a 10-unit increase in ERMI value, 1.8; 95% CI, 1.5-2.2). The summation of levels of 3 mold species, Aspergillus ochraceus , Aspergillus unguis , and Penicillium variabile , was significantly associated with asthma (adjusted relative risk, 2.2; 95% CI, 1.8-2.7). Conclusion In this birth cohort study exposure during infancy to 3 mold species common to water-damaged buildings was associated with childhood asthma at age 7 years. |
| doi_str_mv | 10.1016/j.jaci.2012.05.030 |
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Objective Our hypothesis was that specific mold exposures are associated with childhood asthma development. Methods Infants were identified from birth certificates. Dust samples were collected from 289 homes when the infants were 8 months of age. Samples were analyzed for concentrations of 36 molds that comprise the Environmental Relative Moldiness Index (ERMI) and endotoxin, house dust mite, cat, dog, and cockroach allergens. Children were evaluated at age 7 years for asthma based on reported symptoms and objective measures of lung function. Host, environmental exposure, and home characteristics evaluated included a history of parental asthma, race, sex, upper and lower respiratory tract symptoms, season of birth, family income, cigarette smoke exposure, air conditioning, use of a dehumidifier, presence of carpeting, age of home, and visible mold at age 1 year and child's positive skin prick test response to aeroallergens and molds at age 7 years. Results Asthma was diagnosed in 24% of the children at age 7 years. A statistically significant increase in asthma risk at age 7 years was associated with high ERMI values in the child's home in infancy (adjusted relative risk for a 10-unit increase in ERMI value, 1.8; 95% CI, 1.5-2.2). The summation of levels of 3 mold species, Aspergillus ochraceus , Aspergillus unguis , and Penicillium variabile , was significantly associated with asthma (adjusted relative risk, 2.2; 95% CI, 1.8-2.7). Conclusion In this birth cohort study exposure during infancy to 3 mold species common to water-damaged buildings was associated with childhood asthma at age 7 years.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2012.05.030</identifier><identifier>PMID: 22789397</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Age ; Air conditioning ; Allergens ; Allergies ; Allergy and Immunology ; Antigens ; Aspergillus ochraceus ; Asthma ; Asthma - etiology ; Biological and medical sciences ; Child ; Children ; Chronic obstructive pulmonary disease, asthma ; Cigarette smoke ; Cluster analysis ; Cohort Studies ; Dermatophagoides pteronyssinus ; Dust ; Endotoxins ; Environmental Exposure ; Environmental Relative Moldiness Index ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Fungi - immunology ; Humans ; Immunopathology ; Infant ; Infants ; Lung ; Medical sciences ; Molds ; Nitric oxide ; Outdoor air quality ; Penicillium ; Pneumology ; Races ; Respiratory tract ; Risk assessment ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sex ; Skin tests ; speciation ; Statistical analysis ; Statistical methods ; Studies</subject><ispartof>Journal of allergy and clinical immunology, 2012-09, Vol.130 (3), p.639-644.e5</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2012 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 2012</rights><rights>2012 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-6765bc399d579526b17c3fa570891011df2a4a6304e5f4ca7c2849c811bd8f0e3</citedby><cites>FETCH-LOGICAL-c601t-6765bc399d579526b17c3fa570891011df2a4a6304e5f4ca7c2849c811bd8f0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2012.05.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26346261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22789397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reponen, Tiina, PhD</creatorcontrib><creatorcontrib>Lockey, James, MD, MS</creatorcontrib><creatorcontrib>Bernstein, David I., MD</creatorcontrib><creatorcontrib>Vesper, Stephen J., PhD</creatorcontrib><creatorcontrib>Levin, Linda, PhD</creatorcontrib><creatorcontrib>Khurana Hershey, Gurjit K., MD, PhD</creatorcontrib><creatorcontrib>Zheng, Shu, PhD</creatorcontrib><creatorcontrib>Ryan, Patrick, PhD</creatorcontrib><creatorcontrib>Grinshpun, Sergey A., PhD</creatorcontrib><creatorcontrib>Villareal, Manuel, MD</creatorcontrib><creatorcontrib>LeMasters, Grace, PhD</creatorcontrib><title>Infant origins of childhood asthma associated with specific molds</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background The specific cause or causes of asthma development must be identified to prevent this disease. Objective Our hypothesis was that specific mold exposures are associated with childhood asthma development. Methods Infants were identified from birth certificates. Dust samples were collected from 289 homes when the infants were 8 months of age. Samples were analyzed for concentrations of 36 molds that comprise the Environmental Relative Moldiness Index (ERMI) and endotoxin, house dust mite, cat, dog, and cockroach allergens. Children were evaluated at age 7 years for asthma based on reported symptoms and objective measures of lung function. Host, environmental exposure, and home characteristics evaluated included a history of parental asthma, race, sex, upper and lower respiratory tract symptoms, season of birth, family income, cigarette smoke exposure, air conditioning, use of a dehumidifier, presence of carpeting, age of home, and visible mold at age 1 year and child's positive skin prick test response to aeroallergens and molds at age 7 years. Results Asthma was diagnosed in 24% of the children at age 7 years. A statistically significant increase in asthma risk at age 7 years was associated with high ERMI values in the child's home in infancy (adjusted relative risk for a 10-unit increase in ERMI value, 1.8; 95% CI, 1.5-2.2). The summation of levels of 3 mold species, Aspergillus ochraceus , Aspergillus unguis , and Penicillium variabile , was significantly associated with asthma (adjusted relative risk, 2.2; 95% CI, 1.8-2.7). Conclusion In this birth cohort study exposure during infancy to 3 mold species common to water-damaged buildings was associated with childhood asthma at age 7 years.</description><subject>Age</subject><subject>Air conditioning</subject><subject>Allergens</subject><subject>Allergies</subject><subject>Allergy and Immunology</subject><subject>Antigens</subject><subject>Aspergillus ochraceus</subject><subject>Asthma</subject><subject>Asthma - etiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Children</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cigarette smoke</subject><subject>Cluster analysis</subject><subject>Cohort Studies</subject><subject>Dermatophagoides pteronyssinus</subject><subject>Dust</subject><subject>Endotoxins</subject><subject>Environmental Exposure</subject><subject>Environmental Relative Moldiness Index</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Fungi - immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infants</subject><subject>Lung</subject><subject>Medical sciences</subject><subject>Molds</subject><subject>Nitric oxide</subject><subject>Outdoor air quality</subject><subject>Penicillium</subject><subject>Pneumology</subject><subject>Races</subject><subject>Respiratory tract</subject><subject>Risk assessment</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sex</subject><subject>Skin tests</subject><subject>speciation</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Studies</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl1rFDEUhoModq3-AS9kQAre7JjvTEAKpfhRKHihgnchm49OxplkTWYr_ffNsNtWe-HVIeR5T86b9wDwGsEWQcTfD-2gTWgxRLiFrIUEPgErBKVY8w6zp2AFoURrLqg8Ai9KGWA9k04-B0cYi04SKVbg7CJ6Hecm5XAVYmmSb0wfRtunZBtd5n7StZRkgp6dbf6EuW_K1pngg2mmNNryEjzzeizu1aEegx-fPn4__7K-_Pr54vzscm04RHMdg7ONIVJaJiTDfIOEIV4zATtZ3SDrsaaaE0gd89RoYXBHpekQ2tjOQ0eOwem-73a3mZw1Ls5Zj2qbw6TzjUo6qH9vYujVVbpWhBKMiKgN3h0a5PR758qsplCMG0cdXdoVhRBmGHNMu4q-fYQOaZdjtacQp1QwyDitFN5TJqdSsvP3wyColoTUoJaE1JKQgkzVhKrozd827iV3kVTg5ADoYvTos44mlAeOE8oxR5X7sOdc_fTr4LIqJrhonA3ZmVnZFP4_x-kjuRlDDPXFX-7GlQe_qlSN-rbs0rJKCEPYcfmT3ALmu8MV</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Reponen, Tiina, PhD</creator><creator>Lockey, James, MD, MS</creator><creator>Bernstein, David I., MD</creator><creator>Vesper, Stephen J., PhD</creator><creator>Levin, Linda, PhD</creator><creator>Khurana Hershey, Gurjit K., MD, PhD</creator><creator>Zheng, Shu, PhD</creator><creator>Ryan, Patrick, PhD</creator><creator>Grinshpun, Sergey A., PhD</creator><creator>Villareal, Manuel, MD</creator><creator>LeMasters, Grace, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>20120901</creationdate><title>Infant origins of childhood asthma associated with specific molds</title><author>Reponen, Tiina, PhD ; Lockey, James, MD, MS ; Bernstein, David I., MD ; Vesper, Stephen J., PhD ; Levin, Linda, PhD ; Khurana Hershey, Gurjit K., MD, PhD ; Zheng, Shu, PhD ; Ryan, Patrick, PhD ; Grinshpun, Sergey A., PhD ; Villareal, Manuel, MD ; LeMasters, Grace, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-6765bc399d579526b17c3fa570891011df2a4a6304e5f4ca7c2849c811bd8f0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Air conditioning</topic><topic>Allergens</topic><topic>Allergies</topic><topic>Allergy and Immunology</topic><topic>Antigens</topic><topic>Aspergillus ochraceus</topic><topic>Asthma</topic><topic>Asthma - etiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Children</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cigarette smoke</topic><topic>Cluster analysis</topic><topic>Cohort Studies</topic><topic>Dermatophagoides pteronyssinus</topic><topic>Dust</topic><topic>Endotoxins</topic><topic>Environmental Exposure</topic><topic>Environmental Relative Moldiness Index</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Fungi - immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infants</topic><topic>Lung</topic><topic>Medical sciences</topic><topic>Molds</topic><topic>Nitric oxide</topic><topic>Outdoor air quality</topic><topic>Penicillium</topic><topic>Pneumology</topic><topic>Races</topic><topic>Respiratory tract</topic><topic>Risk assessment</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sex</topic><topic>Skin tests</topic><topic>speciation</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reponen, Tiina, PhD</creatorcontrib><creatorcontrib>Lockey, James, MD, MS</creatorcontrib><creatorcontrib>Bernstein, David I., MD</creatorcontrib><creatorcontrib>Vesper, Stephen J., PhD</creatorcontrib><creatorcontrib>Levin, Linda, PhD</creatorcontrib><creatorcontrib>Khurana Hershey, Gurjit K., MD, PhD</creatorcontrib><creatorcontrib>Zheng, Shu, PhD</creatorcontrib><creatorcontrib>Ryan, Patrick, PhD</creatorcontrib><creatorcontrib>Grinshpun, Sergey A., PhD</creatorcontrib><creatorcontrib>Villareal, Manuel, MD</creatorcontrib><creatorcontrib>LeMasters, Grace, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reponen, Tiina, PhD</au><au>Lockey, James, MD, MS</au><au>Bernstein, David I., MD</au><au>Vesper, Stephen J., PhD</au><au>Levin, Linda, PhD</au><au>Khurana Hershey, Gurjit K., MD, PhD</au><au>Zheng, Shu, PhD</au><au>Ryan, Patrick, PhD</au><au>Grinshpun, Sergey A., PhD</au><au>Villareal, Manuel, MD</au><au>LeMasters, Grace, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infant origins of childhood asthma associated with specific molds</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>130</volume><issue>3</issue><spage>639</spage><epage>644.e5</epage><pages>639-644.e5</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background The specific cause or causes of asthma development must be identified to prevent this disease. Objective Our hypothesis was that specific mold exposures are associated with childhood asthma development. Methods Infants were identified from birth certificates. Dust samples were collected from 289 homes when the infants were 8 months of age. Samples were analyzed for concentrations of 36 molds that comprise the Environmental Relative Moldiness Index (ERMI) and endotoxin, house dust mite, cat, dog, and cockroach allergens. Children were evaluated at age 7 years for asthma based on reported symptoms and objective measures of lung function. Host, environmental exposure, and home characteristics evaluated included a history of parental asthma, race, sex, upper and lower respiratory tract symptoms, season of birth, family income, cigarette smoke exposure, air conditioning, use of a dehumidifier, presence of carpeting, age of home, and visible mold at age 1 year and child's positive skin prick test response to aeroallergens and molds at age 7 years. Results Asthma was diagnosed in 24% of the children at age 7 years. A statistically significant increase in asthma risk at age 7 years was associated with high ERMI values in the child's home in infancy (adjusted relative risk for a 10-unit increase in ERMI value, 1.8; 95% CI, 1.5-2.2). The summation of levels of 3 mold species, Aspergillus ochraceus , Aspergillus unguis , and Penicillium variabile , was significantly associated with asthma (adjusted relative risk, 2.2; 95% CI, 1.8-2.7). Conclusion In this birth cohort study exposure during infancy to 3 mold species common to water-damaged buildings was associated with childhood asthma at age 7 years.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22789397</pmid><doi>10.1016/j.jaci.2012.05.030</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Air conditioning Allergens Allergies Allergy and Immunology Antigens Aspergillus ochraceus Asthma Asthma - etiology Biological and medical sciences Child Children Chronic obstructive pulmonary disease, asthma Cigarette smoke Cluster analysis Cohort Studies Dermatophagoides pteronyssinus Dust Endotoxins Environmental Exposure Environmental Relative Moldiness Index Fundamental and applied biological sciences. Psychology Fundamental immunology Fungi - immunology Humans Immunopathology Infant Infants Lung Medical sciences Molds Nitric oxide Outdoor air quality Penicillium Pneumology Races Respiratory tract Risk assessment Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sex Skin tests speciation Statistical analysis Statistical methods Studies |
| title | Infant origins of childhood asthma associated with specific molds |
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