Chemoselective Covalent Coupling of Oligonucleotide Probes to Self-Assembled Monolayers

A chemoselective route to routinely and rapidly attach oligonucleotide probes to well-defined surfaces is presented. Cu(I) tris(benzyltriazolylmethyl)amine-catalyzed coupling of terminal acetylenes to azides on a self-assembled monolayer is used instead of traditional nucleophilic-electrophilic coup...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2005-06, Vol.127 (24), p.8600-8601
Hauptverfasser:	Devaraj, Neal K, Miller, Gregory P, Ebina, Wataru, Kakaradov, Boyko, Collman, James P, Kool, Eric T, Chidsey, Christopher E. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Biological and medical sciences Copper - chemistry Fundamental and applied biological sciences. Psychology Molecular biophysics Oligonucleotide Probes - chemistry Oligonucleotides - chemistry Organometallic Compounds - chemistry Surface properties. Adsorption Triazoles - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!