The metalloporphyrin antioxidant, MnTE-2-PyP, inhibits Th2 cell immune responses in an asthma model

MnTE-2-PyP, a superoxide dismutase mimetic, inhibited OVA-induced airway inflammation in mice suggesting an effect on Th2 responsiveness. Thus, we hypothesized that MnTE-2-PyP may alter dendritic cell-Th2 interactions. Bone marrow derived dendritic cells (DC) and OVA(323-339)-specific Th2 cells were...

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Veröffentlicht in:	International journal of molecular sciences 2012, Vol.13 (8), p.9785-9797
Hauptverfasser:	Jungsuwadee, Paiboon, Weaver, Michael R, Gally, Fabienne, Oberley-Deegan, Rebecca E
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Allergens Allergies Animals Antigens Antioxidants Antioxidants - pharmacology Asthma Asthma - drug therapy Asthma - immunology Asthma - pathology Cell growth Cell Proliferation - drug effects Cells, Cultured Cytokines Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Disease Models, Animal Flow Cytometry Immune system Inflammation Lymphocytes Metalloporphyrins - pharmacology Mice Mice, Inbred BALB C Ovalbumin - pharmacology Pathogenesis Peptides Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - pathology
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