Derivation of a novel undifferentiated human foetal phenotype in serum‐free cultures with BMP‐2

Skeletal stem and progenitor populations provide a platform for cell‐based tissue regeneration strategies. Optimized conditions for ex vivo expansion will be critical and use of serum‐free culture may allow enhanced modelling of differentiation potential. Maintenance of human foetal femur‐derived ce...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2009-09, Vol.13 (9b), p.3541-3555
Hauptverfasser:	Mirmalek‐Sani, Sayed‐Hadi, Stokes, Paula J., Tare, Rahul S., Ralph, Esther J., Inglis, Stefanie, Hanley, Neil A., Houghton, Franchesca D., Oreffo, Richard O.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins - metabolism Amino acids BMP‐2 Bone Morphogenetic Protein 2 - metabolism Cell culture Cell Differentiation Cell Survival Culture Media, Serum-Free - metabolism differentiation Female Fibroblast Growth Factor 2 - metabolism foetal Gene expression Genotype & phenotype Gestational Age Humans Immunohistochemistry - methods Metabolism Osteogenesis osteoprogenitor Phenotype Pregnancy Proteins Regeneration serum‐free medium Skeletal system Time Factors tissue regeneration Tissue Remodeling/Regeneration
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