Immunopathological patterns from EAE and Theiler's virus infection: Is multiple sclerosis a homogenous 1-stage or heterogenous 2-stage disease?

► Relapsing-remitting (RR) MS transitions to secondary progressive (SP) MS. ► “1-stage” and “2-stage” disease theories explain the transition from RRMS to SPMS. ► 1-stage theory: the effector mechanism remains the same during the disease course. ► 2-stage theory: pathogenesis shifts (e.g. from infla...

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Veröffentlicht in:	Pathophysiology (Amsterdam) 2013-02, Vol.20 (1), p.71-84
Hauptverfasser:	Martinez, Nicholas E., Sato, Fumitaka, Omura, Seiichi, Minagar, Alireza, Alexander, J. Steven, Tsunoda, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Diseases of the Nervous System Central Nervous System Viral Disease CpG oligonucleotides Demyelinating Disease Inside-Out Model Myelin Sheath Picornaviridae Primary Progressive Multiple Sclerosis Seizures Wallerian Degeneration
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