Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature
To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature. 57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation...
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| Veröffentlicht in: | International journal of clinical and experimental pathology 2012-01, Vol.5 (6), p.609-613 |
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| container_title | International journal of clinical and experimental pathology |
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| creator | Pabuccu, Emre Tolunay, Harun Egemen Kocbulut, Evren Taskın, Salih Ortac, Fırat Sertcelik, Ayse Sasmaz, Aysegul Savas, Berna |
| description | To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature.
57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.
Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.
Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases. |
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57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.
Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.
Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.</description><identifier>EISSN: 1936-2625</identifier><identifier>PMID: 22949946</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Case Report ; DNA Mutational Analysis ; DNA, Neoplasm ; Female ; Humans ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local - diagnosis ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins p21(ras) ; ras Proteins - genetics ; ras Proteins - metabolism ; Sigmoid Neoplasms - genetics ; Sigmoid Neoplasms - metabolism ; Sigmoid Neoplasms - pathology ; Vulvar Neoplasms - genetics ; Vulvar Neoplasms - metabolism ; Vulvar Neoplasms - secondary</subject><ispartof>International journal of clinical and experimental pathology, 2012-01, Vol.5 (6), p.609-613</ispartof><rights>IJCEP Copyright © 2012 2012</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430105/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430105/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22949946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pabuccu, Emre</creatorcontrib><creatorcontrib>Tolunay, Harun Egemen</creatorcontrib><creatorcontrib>Kocbulut, Evren</creatorcontrib><creatorcontrib>Taskın, Salih</creatorcontrib><creatorcontrib>Ortac, Fırat</creatorcontrib><creatorcontrib>Sertcelik, Ayse</creatorcontrib><creatorcontrib>Sasmaz, Aysegul</creatorcontrib><creatorcontrib>Savas, Berna</creatorcontrib><title>Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature</title><title>International journal of clinical and experimental pathology</title><addtitle>Int J Clin Exp Pathol</addtitle><description>To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature.
57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.
Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.
Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Case Report</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Neoplasm</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins p21(ras)</subject><subject>ras Proteins - genetics</subject><subject>ras Proteins - metabolism</subject><subject>Sigmoid Neoplasms - genetics</subject><subject>Sigmoid Neoplasms - metabolism</subject><subject>Sigmoid Neoplasms - pathology</subject><subject>Vulvar Neoplasms - genetics</subject><subject>Vulvar Neoplasms - metabolism</subject><subject>Vulvar Neoplasms - secondary</subject><issn>1936-2625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE9LxDAQxYsg7rr6FSRHLwtp0qaNB0EW_8GCFz2XaXayG22TmqQVv71ZXEVPMzBvfu_NHGXzXHKxZIKVs-w0hFdKRc4KepLNGJOFlIWYZ3YNEYlHNXqPViFxmgSz7Z3ZEAVeGet6IL3pjXozdksGb3rwn2Qauwl8kqQdf5Vq2FMG5yMBu0ntZPBjD4s7JJ2J6CGOHs-yYw1dwPNDXWQvd7fPq4fl-un-cXWzXg5MiLhMuWULtSprrisAUSvZVhyhbrFSoKWu8iJnoNIdZYG6FZrWQnGNrGUq14Ivsutv7jC2PW4U2uihaw7pGwem-T-xZtds3dTwgtOclglweQB49z5iiE1vgsKuA4tuDE1OeZ3caSWT9OKv16_Jz5P5F2j7e5Q</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Pabuccu, Emre</creator><creator>Tolunay, Harun Egemen</creator><creator>Kocbulut, Evren</creator><creator>Taskın, Salih</creator><creator>Ortac, Fırat</creator><creator>Sertcelik, Ayse</creator><creator>Sasmaz, Aysegul</creator><creator>Savas, Berna</creator><general>e-Century Publishing Corporation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature</title><author>Pabuccu, Emre ; 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57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.
Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.
Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>22949946</pmid><tpages>5</tpages></addata></record> |
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| ispartof | International journal of clinical and experimental pathology, 2012-01, Vol.5 (6), p.609-613 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Case Report DNA Mutational Analysis DNA, Neoplasm Female Humans Middle Aged Mutation Neoplasm Recurrence, Local - diagnosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) ras Proteins - genetics ras Proteins - metabolism Sigmoid Neoplasms - genetics Sigmoid Neoplasms - metabolism Sigmoid Neoplasms - pathology Vulvar Neoplasms - genetics Vulvar Neoplasms - metabolism Vulvar Neoplasms - secondary |
| title | Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature |
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