Effect of Sampling Volume on Dry Powder Inhaler (DPI)-Emitted Aerosol Aerodynamic Particle Size Distributions (APSDs) Measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI)

Current pharmacopeial methods for testing dry powder inhalers (DPIs) require that 4.0 L be drawn through the inhaler to quantify aerodynamic particle size distribution of “inhaled” particles. This volume comfortably exceeds the internal dead volume of the Andersen eight-stage cascade impactor (ACI)...

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Veröffentlicht in:	AAPS PharmSciTech 2012-09, Vol.13 (3), p.875-882
Hauptverfasser:	Mohammed, Hlack, Roberts, Daryl L., Copley, Mark, Hammond, Mark, Nichols, Steven C., Mitchell, Jolyon P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Dry Powder Inhalers - instrumentation Dry Powder Inhalers - methods Equipment Design - instrumentation Equipment Design - methods Particle Size Pharmacology/Toxicology Pharmacy Research Article Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods
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