Manganese Superoxide Dismutase Regulates a Metabolic Switch during the Mammalian Cell Cycle

Proliferating cells consume more glucose to cope with the bioenergetics and biosynthetic demands of rapidly dividing cells as well as to counter a shift in cellular redox environment. This study investigates the hypothesis that manganese superoxide dismutase (MnSOD) regulates cellular redox flux and...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-08, Vol.72 (15), p.3807-3816
Hauptverfasser:	SARSOUR, Ehab H, KALEN, Amanda L, ZHEN XIAO, VEENSTRA, Timothy D, CHAUDHURI, Leena, VENKATARAMAN, Sujatha, REIGAN, Philip, BUETTNER, Garry R, GOSWAMI, Prabhat C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Cycle - genetics Cell Cycle - physiology Cell Proliferation Cells, Cultured Embryo, Mammalian Energy Metabolism - genetics Energy Metabolism - physiology Gene Knockout Techniques Glucose - metabolism Humans Mammals - genetics Mammals - metabolism Mammals - physiology Medical sciences Metabolic Networks and Pathways - physiology Mice Models, Molecular Oxygen - metabolism Pharmacology. Drug treatments Superoxide Dismutase - chemistry Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase - physiology Transfection Tumors
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