Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state

Classical dendritic cells (cDCs) process and present antigens to T cells. Under steady-state conditions, antigen presentation by cDCs induces tolerance. In contrast, during infection or inflammation, cDCs become activated, express higher levels of cell surface MHC molecules, and induce strong adapti...

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Veröffentlicht in:	The Journal of experimental medicine 2012-08, Vol.209 (9), p.1583-1593
Hauptverfasser:	Meredith, Matthew M, Liu, Kang, Kamphorst, Alice O, Idoyaga, Juliana, Yamane, Arito, Guermonprez, Pierre, Rihn, Suzannah, Yao, Kai-Hui, Silva, Israel T, Oliveira, Thiago Y, Skokos, Dimitris, Casellas, Rafael, Nussenzweig, Michel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin Immunoprecipitation Dendritic Cells - immunology Dendritic Cells - physiology Gene Expression Regulation Lymphangiogenesis - genetics Mice Mice, Knockout Promoter Regions, Genetic Toll-Like Receptors - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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