Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis
Objective To profile the abundance and diversity of subgingival oral microbiota in patients with never‐treated, new‐onset rheumatoid arthritis (RA). Methods Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new‐onset RA, patients with c...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2012-10, Vol.64 (10), p.3083-3094 |
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| creator | Scher, Jose U. Ubeda, Carles Equinda, Michele Khanin, Raya Buischi, Yvonne Viale, Agnes Lipuma, Lauren Attur, Mukundan Pillinger, Michael H. Weissmann, Gerald Littman, Dan R. Pamer, Eric G. Bretz, Walter A. Abramson, Steven B. |
| description | Objective
To profile the abundance and diversity of subgingival oral microbiota in patients with never‐treated, new‐onset rheumatoid arthritis (RA).
Methods
Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new‐onset RA, patients with chronic RA, and healthy subjects. Multiplexed‐454 pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between the presence/abundance of bacteria and disease phenotypes. Anti–Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis.
Results
The more advanced forms of periodontitis were already present at disease onset in patients with new‐onset RA. The subgingival microbiota observed in patients with new‐onset RA was distinct from that found in healthy controls. In most cases, however, these microbial differences could be attributed to the severity of PD and were not inherent to RA. The presence and abundance of P gingivalis were also directly associated with the severity of PD and were not unique to RA. The presence of P gingivalis was not correlated with anti–citrullinated protein antibody (ACPA) titers. Overall exposure to P gingivalis was similar between patients with new‐onset RA and controls, observed in 78% of patients and 83% of controls. The presence and abundance of Anaeroglobus geminatus correlated with the presence of ACPAs/rheumatoid factor. Prevotella and Leptotrichia species were the only characteristic taxa observed in patients with new‐onset RA irrespective of PD status.
Conclusion
Patients with new‐onset RA exhibited a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota profile in patients with new‐onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity. Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. The role of A geminatus and Prevotella/Leptotrichia species in this process merits further study. |
| doi_str_mv | 10.1002/art.34539 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3428472</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3277918981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6109-5e98b10ed40bd6fa6fc1c2c0b2d184e4a47b8753e5507354f57f01e20450a3653</originalsourceid><addsrcrecordid>eNqFkVtv1DAQhS0EotvCA38ARUJI8JB2fE9ekKrSC1K5L4I3y0kmrEsSF9tL6b_Hy26Xi4R4suz55pzxHEIeUNinAOzAhrTPheT1LTKjktUlUE5vkxkAiJLLmu6Q3Rgv8pVxye-SHcakVkyxGXn5BoPznZ-SHYrORbQRCzt1RVpg4UN-HF0bfON8soWbigmvSj9FTEVY4HK0ybuuyP6L4JKL98id3g4R72_OPfLh5Hh-dFaevz59cXR4XraKQl1KrKuGAnYCmk71VvUtbVkLDetoJVBYoZtKS45SguZS9FL3QJGBkGC5knyPPFvrXi6bEbsWp5RHNZfBjTZcG2-d-bMyuYX57L8ZLlglNMsCTzYCwX9dYkxmdLHFYbAT-mU0VNWiVrWk8H8UKlppqoTO6KO_0Au_DFPehKGS6pwVwIp6uqbyXmMM2G_npmBWeZq8T_Mzz8w-_P2jW_ImwAw83gA2tnbog51aF39xSnEp1cr0YM1duQGv_-1oDt_Nb6zLdYeLCb9vO2z4YrKelubjq1NzVqn58_cnn8xb_gNJlMVy</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517100007</pqid></control><display><type>article</type><title>Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Scher, Jose U. ; Ubeda, Carles ; Equinda, Michele ; Khanin, Raya ; Buischi, Yvonne ; Viale, Agnes ; Lipuma, Lauren ; Attur, Mukundan ; Pillinger, Michael H. ; Weissmann, Gerald ; Littman, Dan R. ; Pamer, Eric G. ; Bretz, Walter A. ; Abramson, Steven B.</creator><creatorcontrib>Scher, Jose U. ; Ubeda, Carles ; Equinda, Michele ; Khanin, Raya ; Buischi, Yvonne ; Viale, Agnes ; Lipuma, Lauren ; Attur, Mukundan ; Pillinger, Michael H. ; Weissmann, Gerald ; Littman, Dan R. ; Pamer, Eric G. ; Bretz, Walter A. ; Abramson, Steven B.</creatorcontrib><description>Objective
To profile the abundance and diversity of subgingival oral microbiota in patients with never‐treated, new‐onset rheumatoid arthritis (RA).
Methods
Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new‐onset RA, patients with chronic RA, and healthy subjects. Multiplexed‐454 pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between the presence/abundance of bacteria and disease phenotypes. Anti–Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis.
Results
The more advanced forms of periodontitis were already present at disease onset in patients with new‐onset RA. The subgingival microbiota observed in patients with new‐onset RA was distinct from that found in healthy controls. In most cases, however, these microbial differences could be attributed to the severity of PD and were not inherent to RA. The presence and abundance of P gingivalis were also directly associated with the severity of PD and were not unique to RA. The presence of P gingivalis was not correlated with anti–citrullinated protein antibody (ACPA) titers. Overall exposure to P gingivalis was similar between patients with new‐onset RA and controls, observed in 78% of patients and 83% of controls. The presence and abundance of Anaeroglobus geminatus correlated with the presence of ACPAs/rheumatoid factor. Prevotella and Leptotrichia species were the only characteristic taxa observed in patients with new‐onset RA irrespective of PD status.
Conclusion
Patients with new‐onset RA exhibited a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota profile in patients with new‐onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity. Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. The role of A geminatus and Prevotella/Leptotrichia species in this process merits further study.</description><identifier>ISSN: 0004-3591</identifier><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 1529-0131</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.34539</identifier><identifier>PMID: 22576262</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - microbiology ; Biological and medical sciences ; Diseases of the osteoarticular system ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Humans ; Inflammatory joint diseases ; Leptotrichia ; Male ; Medical research ; Medical sciences ; Metagenome ; Middle Aged ; Mouth - immunology ; Mouth - microbiology ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Periodontitis - complications ; Periodontitis - immunology ; Periodontitis - microbiology ; Porphyromonas gingivalis - immunology ; Prevotella ; Rheumatoid arthritis ; Severity of Illness Index ; Socioeconomic Factors ; Surveys and Questionnaires</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2012-10, Vol.64 (10), p.3083-3094</ispartof><rights>Copyright © 2012 by the American College of Rheumatology</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 by the American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6109-5e98b10ed40bd6fa6fc1c2c0b2d184e4a47b8753e5507354f57f01e20450a3653</citedby><cites>FETCH-LOGICAL-c6109-5e98b10ed40bd6fa6fc1c2c0b2d184e4a47b8753e5507354f57f01e20450a3653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.34539$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.34539$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26635567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22576262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scher, Jose U.</creatorcontrib><creatorcontrib>Ubeda, Carles</creatorcontrib><creatorcontrib>Equinda, Michele</creatorcontrib><creatorcontrib>Khanin, Raya</creatorcontrib><creatorcontrib>Buischi, Yvonne</creatorcontrib><creatorcontrib>Viale, Agnes</creatorcontrib><creatorcontrib>Lipuma, Lauren</creatorcontrib><creatorcontrib>Attur, Mukundan</creatorcontrib><creatorcontrib>Pillinger, Michael H.</creatorcontrib><creatorcontrib>Weissmann, Gerald</creatorcontrib><creatorcontrib>Littman, Dan R.</creatorcontrib><creatorcontrib>Pamer, Eric G.</creatorcontrib><creatorcontrib>Bretz, Walter A.</creatorcontrib><creatorcontrib>Abramson, Steven B.</creatorcontrib><title>Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis & Rheumatism</addtitle><description>Objective
To profile the abundance and diversity of subgingival oral microbiota in patients with never‐treated, new‐onset rheumatoid arthritis (RA).
Methods
Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new‐onset RA, patients with chronic RA, and healthy subjects. Multiplexed‐454 pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between the presence/abundance of bacteria and disease phenotypes. Anti–Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis.
Results
The more advanced forms of periodontitis were already present at disease onset in patients with new‐onset RA. The subgingival microbiota observed in patients with new‐onset RA was distinct from that found in healthy controls. In most cases, however, these microbial differences could be attributed to the severity of PD and were not inherent to RA. The presence and abundance of P gingivalis were also directly associated with the severity of PD and were not unique to RA. The presence of P gingivalis was not correlated with anti–citrullinated protein antibody (ACPA) titers. Overall exposure to P gingivalis was similar between patients with new‐onset RA and controls, observed in 78% of patients and 83% of controls. The presence and abundance of Anaeroglobus geminatus correlated with the presence of ACPAs/rheumatoid factor. Prevotella and Leptotrichia species were the only characteristic taxa observed in patients with new‐onset RA irrespective of PD status.
Conclusion
Patients with new‐onset RA exhibited a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota profile in patients with new‐onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity. Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. The role of A geminatus and Prevotella/Leptotrichia species in this process merits further study.</description><subject>Adult</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - microbiology</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Leptotrichia</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metagenome</subject><subject>Middle Aged</subject><subject>Mouth - immunology</subject><subject>Mouth - microbiology</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Periodontitis - complications</subject><subject>Periodontitis - immunology</subject><subject>Periodontitis - microbiology</subject><subject>Porphyromonas gingivalis - immunology</subject><subject>Prevotella</subject><subject>Rheumatoid arthritis</subject><subject>Severity of Illness Index</subject><subject>Socioeconomic Factors</subject><subject>Surveys and Questionnaires</subject><issn>0004-3591</issn><issn>2326-5191</issn><issn>1529-0131</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtv1DAQhS0EotvCA38ARUJI8JB2fE9ekKrSC1K5L4I3y0kmrEsSF9tL6b_Hy26Xi4R4suz55pzxHEIeUNinAOzAhrTPheT1LTKjktUlUE5vkxkAiJLLmu6Q3Rgv8pVxye-SHcakVkyxGXn5BoPznZ-SHYrORbQRCzt1RVpg4UN-HF0bfON8soWbigmvSj9FTEVY4HK0ybuuyP6L4JKL98id3g4R72_OPfLh5Hh-dFaevz59cXR4XraKQl1KrKuGAnYCmk71VvUtbVkLDetoJVBYoZtKS45SguZS9FL3QJGBkGC5knyPPFvrXi6bEbsWp5RHNZfBjTZcG2-d-bMyuYX57L8ZLlglNMsCTzYCwX9dYkxmdLHFYbAT-mU0VNWiVrWk8H8UKlppqoTO6KO_0Au_DFPehKGS6pwVwIp6uqbyXmMM2G_npmBWeZq8T_Mzz8w-_P2jW_ImwAw83gA2tnbog51aF39xSnEp1cr0YM1duQGv_-1oDt_Nb6zLdYeLCb9vO2z4YrKelubjq1NzVqn58_cnn8xb_gNJlMVy</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Scher, Jose U.</creator><creator>Ubeda, Carles</creator><creator>Equinda, Michele</creator><creator>Khanin, Raya</creator><creator>Buischi, Yvonne</creator><creator>Viale, Agnes</creator><creator>Lipuma, Lauren</creator><creator>Attur, Mukundan</creator><creator>Pillinger, Michael H.</creator><creator>Weissmann, Gerald</creator><creator>Littman, Dan R.</creator><creator>Pamer, Eric G.</creator><creator>Bretz, Walter A.</creator><creator>Abramson, Steven B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201210</creationdate><title>Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis</title><author>Scher, Jose U. ; Ubeda, Carles ; Equinda, Michele ; Khanin, Raya ; Buischi, Yvonne ; Viale, Agnes ; Lipuma, Lauren ; Attur, Mukundan ; Pillinger, Michael H. ; Weissmann, Gerald ; Littman, Dan R. ; Pamer, Eric G. ; Bretz, Walter A. ; Abramson, Steven B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6109-5e98b10ed40bd6fa6fc1c2c0b2d184e4a47b8753e5507354f57f01e20450a3653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - microbiology</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Leptotrichia</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metagenome</topic><topic>Middle Aged</topic><topic>Mouth - immunology</topic><topic>Mouth - microbiology</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Periodontitis - complications</topic><topic>Periodontitis - immunology</topic><topic>Periodontitis - microbiology</topic><topic>Porphyromonas gingivalis - immunology</topic><topic>Prevotella</topic><topic>Rheumatoid arthritis</topic><topic>Severity of Illness Index</topic><topic>Socioeconomic Factors</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scher, Jose U.</creatorcontrib><creatorcontrib>Ubeda, Carles</creatorcontrib><creatorcontrib>Equinda, Michele</creatorcontrib><creatorcontrib>Khanin, Raya</creatorcontrib><creatorcontrib>Buischi, Yvonne</creatorcontrib><creatorcontrib>Viale, Agnes</creatorcontrib><creatorcontrib>Lipuma, Lauren</creatorcontrib><creatorcontrib>Attur, Mukundan</creatorcontrib><creatorcontrib>Pillinger, Michael H.</creatorcontrib><creatorcontrib>Weissmann, Gerald</creatorcontrib><creatorcontrib>Littman, Dan R.</creatorcontrib><creatorcontrib>Pamer, Eric G.</creatorcontrib><creatorcontrib>Bretz, Walter A.</creatorcontrib><creatorcontrib>Abramson, Steven B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scher, Jose U.</au><au>Ubeda, Carles</au><au>Equinda, Michele</au><au>Khanin, Raya</au><au>Buischi, Yvonne</au><au>Viale, Agnes</au><au>Lipuma, Lauren</au><au>Attur, Mukundan</au><au>Pillinger, Michael H.</au><au>Weissmann, Gerald</au><au>Littman, Dan R.</au><au>Pamer, Eric G.</au><au>Bretz, Walter A.</au><au>Abramson, Steven B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis & Rheumatism</addtitle><date>2012-10</date><risdate>2012</risdate><volume>64</volume><issue>10</issue><spage>3083</spage><epage>3094</epage><pages>3083-3094</pages><issn>0004-3591</issn><issn>2326-5191</issn><eissn>1529-0131</eissn><eissn>2326-5205</eissn><coden>ARHEAW</coden><abstract>Objective
To profile the abundance and diversity of subgingival oral microbiota in patients with never‐treated, new‐onset rheumatoid arthritis (RA).
Methods
Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new‐onset RA, patients with chronic RA, and healthy subjects. Multiplexed‐454 pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between the presence/abundance of bacteria and disease phenotypes. Anti–Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis.
Results
The more advanced forms of periodontitis were already present at disease onset in patients with new‐onset RA. The subgingival microbiota observed in patients with new‐onset RA was distinct from that found in healthy controls. In most cases, however, these microbial differences could be attributed to the severity of PD and were not inherent to RA. The presence and abundance of P gingivalis were also directly associated with the severity of PD and were not unique to RA. The presence of P gingivalis was not correlated with anti–citrullinated protein antibody (ACPA) titers. Overall exposure to P gingivalis was similar between patients with new‐onset RA and controls, observed in 78% of patients and 83% of controls. The presence and abundance of Anaeroglobus geminatus correlated with the presence of ACPAs/rheumatoid factor. Prevotella and Leptotrichia species were the only characteristic taxa observed in patients with new‐onset RA irrespective of PD status.
Conclusion
Patients with new‐onset RA exhibited a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota profile in patients with new‐onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity. Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. The role of A geminatus and Prevotella/Leptotrichia species in this process merits further study.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22576262</pmid><doi>10.1002/art.34539</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2012-10, Vol.64 (10), p.3083-3094 |
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| subjects | Adult Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - microbiology Biological and medical sciences Diseases of the osteoarticular system Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Humans Inflammatory joint diseases Leptotrichia Male Medical research Medical sciences Metagenome Middle Aged Mouth - immunology Mouth - microbiology Non tumoral diseases Otorhinolaryngology. Stomatology Periodontitis - complications Periodontitis - immunology Periodontitis - microbiology Porphyromonas gingivalis - immunology Prevotella Rheumatoid arthritis Severity of Illness Index Socioeconomic Factors Surveys and Questionnaires |
| title | Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis |
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