Aromatase, breast cancer and obesity: a complex interaction

Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, increased local estrogen production, and predisposition to breast hyperplasia and cancer. Increased adiposity in postmenopausal women may trigger signaling pathways that induce aromatase expression. In...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2012-02, Vol.23 (2), p.83-89
Hauptverfasser:	Bulun, Serdar E, Chen, Dong, Moy, Irene, Brooks, David C, Zhao, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose Tissue - pathology Aromatase - biosynthesis Aromatase - metabolism Biological and medical sciences Breast - metabolism Breast - pathology Breast Neoplasms - etiology Breast Neoplasms - metabolism Breast Neoplasms - pathology Endocrinology & Metabolism Estrogens - biosynthesis Female Fibroblasts - enzymology Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Metabolic diseases Obesity Obesity - complications Obesity - physiopathology Paracrine Communication - physiology Signal Transduction - physiology Tumors Vertebrates: endocrinology
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