CD4 T follicular helper cell dynamics during SIV infection

CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their participation in SIV-induced antibody production is not w...

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Veröffentlicht in:	The Journal of clinical investigation 2012-09, Vol.122 (9), p.3281-3294
Hauptverfasser:	Petrovas, Constantinos, Yamamoto, Takuya, Gerner, Michael Y, Boswell, Kristin L, Wloka, Kaska, Smith, Emily C, Ambrozak, David R, Sandler, Netanya G, Timmer, Katherina J, Sun, Xiaoyong, Pan, Li, Poholek, Amanda, Rao, Srinivas S, Brenchley, Jason M, Alam, S Munir, Tomaras, Georgia D, Roederer, Mario, Douek, Daniel C, Seder, Robert A, Germain, Ronald N, Haddad, Elias K, Koup, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Antigens B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedical research CD4 Antigens - metabolism CD4 lymphocytes Cell Death Cell Proliferation Cells Cytokines - metabolism Flow cytometry Gene Expression Genetic aspects Genotype & phenotype Germinal Center - pathology Germinal Center - virology Host-Pathogen Interactions Immunoglobulins Infections Localization Lymph Nodes - metabolism Lymph Nodes - pathology Lymph Nodes - virology Lymphocytes Macaca mulatta Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-maf - genetics Proto-Oncogene Proteins c-maf - metabolism Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism Simian Acquired Immunodeficiency Syndrome - blood Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - pathology Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - physiology T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcriptome
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