Deficiency in frataxin homologue YFH1 in the yeast Pichia guilliermondii leads to missregulation of iron acquisition and riboflavin biosynthesis and affects sulfate assimilation

Pichia guilliermondii is a representative of yeast species that overproduce riboflavin (vitamin B₂) in response to iron deprivation. P. guilliermondii YFH1 gene coding for frataxin homologue, eukaryotic mitochondrial protein involved in iron trafficking and storage, was identified and deleted. Const...

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Veröffentlicht in:	Biometals 2009-12, Vol.22 (6), p.1051-1061
Hauptverfasser:	Pynyaha, Yuriy V, Boretsky, Yuriy R, Fedorovych, Daria V, Fayura, Lubov R, Levkiv, Andriy I, Ubiyvovk, Vira M, Protchenko, Olha V, Philpott, Caroline C, Sibirny, Andriy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biosynthesis Carbon sources Cell Biology Cellular biology Frataxin Fungal Proteins - genetics Fungal Proteins - metabolism Gene Deletion Glycerol - metabolism Hydrogen peroxide Hydrogen Peroxide - pharmacology Hypersensitivity Ion Transport - drug effects Ion Transport - genetics Iron Iron - metabolism Iron-Binding Proteins - genetics Iron-Binding Proteins - metabolism Life Sciences Medicine/Public Health Metabolism Microbiology Mitochondria - metabolism Mutants Mutation Organisms, Genetically Modified - genetics Organisms, Genetically Modified - metabolism Oxygen uptake Pharmacology/Toxicology Pichia - genetics Pichia - metabolism Pichia guilliermondii Plant Physiology Proteins Riboflavin - biosynthesis Riboflavin - genetics Riboflavin - pharmacology Succinic Acid - metabolism Sucrose - metabolism Sulfates Sulfur Sulfur Compounds - metabolism Sulfuric Acid Esters - metabolism Superoxide Dismutase - analysis Yeast Yeasts
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