Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system

Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that modulate healthy aging. In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily apparent, but because dendrite restructuring and loss of synaptic integrity are hy...

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Veröffentlicht in:	The Journal of neuroscience 2012-06, Vol.32 (26), p.8778-8790
Hauptverfasser:	Toth, Marton Lorant, Melentijevic, Ilija, Shah, Leena, Bhatia, Aatish, Lu, Kevin, Talwar, Amish, Naji, Haaris, Ibanez-Ventoso, Carolina, Ghose, Piya, Jevince, Angela, Xue, Jian, Herndon, Laura A, Bhanot, Gyan, Rongo, Chris, Hall, David H, Driscoll, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - pathology Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Forkhead Transcription Factors Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Microscopy, Electron, Transmission Mitochondria - ultrastructure Mutation - genetics Nematoda Nervous System - cytology Neurites - physiology Neurites - ultrastructure Neurons - classification Neurons - cytology Neurons - ultrastructure Receptor, Insulin - metabolism Signal Transduction - physiology Synapses - pathology Synapses - ultrastructure Touch - physiology Transcription Factors - genetics Transcription Factors - metabolism
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