Antibiotics, microbiota, and immune defense
The gastrointestinal tract microbiota contributes to the development and differentiation of the mammalian immune system. The composition of the microbiota affects immune responses and affects susceptibility to infection by intestinal pathogens and development of allergic and inflammatory bowel disea...
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| Veröffentlicht in: | Trends in immunology 2012-09, Vol.33 (9), p.459-466 |
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| container_end_page | 466 |
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| container_title | Trends in immunology |
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| creator | Ubeda, Carles Pamer, Eric G |
| description | The gastrointestinal tract microbiota contributes to the development and differentiation of the mammalian immune system. The composition of the microbiota affects immune responses and affects susceptibility to infection by intestinal pathogens and development of allergic and inflammatory bowel diseases. Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities and decreases host resistance to antibiotic-resistant microbes. Here, we review recent advances that begin to define the interactions between complex intestinal microbial populations and the mammalian immune system and how this relation is perturbed by antibiotic administration. We further discuss how antibiotic-induced disruption of the microbiota and immune homeostasis can lead to disease and we review strategies to restore immune defenses during antibiotic administration. |
| doi_str_mv | 10.1016/j.it.2012.05.003 |
| format | Article |
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| ispartof | Trends in immunology, 2012-09, Vol.33 (9), p.459-466 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | allergy Allergy and Immunology Animals Anti-Bacterial Agents - pharmacology antibiotic resistance Antibiotics Apoptosis Bacteria Bacterial infections Cytokines gastrointestinal system Gram-positive bacteria homeostasis Homeostasis - drug effects Humans immune response Immune system Immune System - drug effects immunity Immunity, Mucosal - drug effects infection Infections Inflammatory bowel disease Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Large intestine Ligands mammals Metagenome - drug effects microbial communities microbiota microorganisms pathogens Proteins Small intestine Viral infections |
| title | Antibiotics, microbiota, and immune defense |
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