Catalytic Zinc Site and Mechanism of the Metalloenzyme PR-AMP Cyclohydrolase

The enzyme N 1-(5′-phosphoribosyl) adenosine-5′-monophosphate cyclohydrolase (PR-AMP cyclohydrolase) is a Zn2+ metalloprotein encoded by the hisI gene. It catalyzes the third step of histidine biosynthesis, an uncommon ring-opening of a purine heterocycle for use in primary metabolism. A three-dimen...

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Veröffentlicht in:	Biochemistry (Easton) 2012-07, Vol.51 (29), p.5791-5803
Hauptverfasser:	D’Ordine, Robert L, Linger, Rebecca S, Thai, Carolyn J, Davisson, V. Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Catalytic Domain Cysteine - chemistry Cysteine - genetics Cysteine - metabolism Dithionitrobenzoic Acid - pharmacology Hydrolases - antagonists & inhibitors Hydrolases - chemistry Hydrolases - genetics Hydrolases - metabolism Magnesium - metabolism Metalloproteins - antagonists & inhibitors Metalloproteins - chemistry Metalloproteins - genetics Metalloproteins - metabolism Methanococcus - chemistry Methanococcus - enzymology Methanococcus - genetics Models, Molecular Molecular Sequence Data Point Mutation Sequence Alignment Zinc - metabolism
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