Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries
Throughout history, poor quality medicines have been a persistent problem, with periodical crises in the supply of antimicrobials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Regrettably, this problem seems to have grown in the last decade, especially afflicting unsuspecti...
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| Veröffentlicht in: | Analyst (London) 2011-08, Vol.136 (15), p.3073-3082 |
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| container_title | Analyst (London) |
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| creator | FERNANDEZ, Facundo M HOSTETLER, Dana POWELL, Kristen KAUR, Harparkash GREEN, Michael D MILDENHALL, Dallas C NEWTON, Paul N |
| description | Throughout history, poor quality medicines have been a persistent problem, with periodical crises in the supply of antimicrobials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Regrettably, this problem seems to have grown in the last decade, especially afflicting unsuspecting patients and those seeking medicines via on-line pharmacies. Here we discuss some of the challenges related to the fight against poor quality drugs, and counterfeits in particular, with an emphasis on the analytical tools available, their relative performance, and the necessary workflows needed for distinguishing between genuine, substandard, degraded and counterfeit medicines. |
| doi_str_mv | 10.1039/c0an00627k |
| format | Article |
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| ispartof | Analyst (London), 2011-08, Vol.136 (15), p.3073-3082 |
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| source | Royal Society of Chemistry Journals Archive (1841-2007); MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Analytical chemistry Chemistry Counterfeit Drugs - chemistry Databases, Factual Developing Countries Drug Contamination Drug Stability Exact sciences and technology Fraud - trends Mass Spectrometry - methods Pharmaceutical Preparations - chemistry Quality Control Spectrophotometry, Infrared - methods Spectrum Analysis, Raman - methods |
| title | Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries |
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